{ "abstract": "Osteoarthritis (OA) is a progressive whole-joint disorder involving cartilage degeneration, oxidative stress, synovial inflammation, and subchondral bone remodeling. Current treatments mainly provide symptomatic relief and rarely restore joint microenvironmental homeostasis. Here, we developed a multifunctional near-infrared (NIR)-responsive CuTA@PDA@PTH nanozyme, termed CPP, for OA therapy. CPP was constructed through copper-tannic acid coordination, polydopamine coating, and PTH 1-34 incorporation, integrating antioxidant catalytic activity, photothermal responsiveness, and peptide-mediated bioactivity. CPP exhibited uniform morphology, good dispersibility, stable photothermal behavior, and broad-spectrum ROS-scavenging activity with SOD-like and CAT-like functions. In vitro, NIR-activated CPP reduced H₂O₂-induced ROS accumulation, lipid peroxidation, mitochondrial dysfunction, and apoptosis in chondrocytes, while promoting proliferation and restoring cartilage matrix homeostasis. CPP-NIR also downregulated inflammatory and catabolic markers, attenuated M1-associated activation, favored an anti-inflammatory M2-like phenotype, and enhanced BMSC migration and osteogenic differentiation under oxidative stress. In a DMM-induced mouse OA model, intra-articular CPP combined with NIR irradiation prolonged joint retention, attenuated cartilage degeneration, reduced osteophyte formation, improved subchondral bone microarchitecture, and alleviated synovial inflammation. These findings support NIR-activated CPP as a multi-axis nanozyme platform for redox, immune, cartilage, and subchondral bone microenvironment regulation in OA.", "abstract_shown": true, "affiliations": [ "Department of Orthopedics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.", "Department of Orthopedics, Fujian Provincial Hospital, School of Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.", "Fujian Provincial Clinical Research Center for Spinal Nerve and Joint Diseases, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.", "Engineering Research Center of Orthopedic Biomaterials, Fujian Province University, Fuzhou University, Fuzhou, Fujian, China.", "Fujian Provincial Scoliosis Diagnosis and Treatment Center, Fuazhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.", "Department of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.", "Department of Orthopedics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. jiexud@126.com.", "Department of Orthopedics, Fujian Provincial Hospital, School of Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. jiexud@126.com.", "Fujian Provincial Clinical Research Center for Spinal Nerve and Joint Diseases, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. jiexud@126.com.", "Engineering Research Center of Orthopedic Biomaterials, Fujian Province University, Fuzhou University, Fuzhou, Fujian, China. jiexud@126.com.", "Fujian Provincial Scoliosis Diagnosis and Treatment Center, Fuazhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. jiexud@126.com.", "Department of Orthopedics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. resoluto@foxmail.com.", "Department of Orthopedics, Fujian Provincial Hospital, School of Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. resoluto@foxmail.com.", "Fujian Provincial Clinical Research Center for Spinal Nerve and Joint Diseases, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. resoluto@foxmail.com.", "Engineering Research Center of Orthopedic Biomaterials, Fujian Province University, Fuzhou University, Fuzhou, Fujian, China. resoluto@foxmail.com.", "Fujian Provincial Scoliosis Diagnosis and Treatment Center, Fuazhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. resoluto@foxmail.com.", "Department of Orthopedics, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. yuyunlong@fzu.edu.cn.", "Department of Orthopedics, Fujian Provincial Hospital, School of Medicine, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. yuyunlong@fzu.edu.cn.", "Fujian Provincial Clinical Research Center for Spinal Nerve and Joint Diseases, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. yuyunlong@fzu.edu.cn.", "Engineering Research Center of Orthopedic Biomaterials, Fujian Province University, Fuzhou University, Fuzhou, Fujian, China. yuyunlong@fzu.edu.cn.", "Fujian Provincial Scoliosis Diagnosis and Treatment Center, Fuazhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China. yuyunlong@fzu.edu.cn." ], "article_type": "research article", "arxiv": null, "author_total": 12, "authors": [ { "affs": [ 0, 1, 2, 3, 4 ], "name": "Zhao Lin" }, { "affs": [ 0, 1, 2, 3, 4 ], "name": "Jiayao Zhang" }, { "affs": [ 0, 1, 2, 3, 4 ], "name": "Mingjuan Zhang" }, { "affs": [ 0, 1, 2, 3, 4 ], "name": "Mukun Xiao" }, { "affs": [ 0, 1, 2, 3, 4 ], "name": "Hanhao Dai" }, { "affs": [ 1, 5, 2, 3, 4 ], "name": "Yibin Su" }, { "affs": [ 0, 1, 2, 3, 4 ], "name": "Haiqi Ding" }, { "affs": [ 0, 1, 2, 3, 4 ], "name": "Dingqiang Chen" }, { "affs": [ 0, 1, 2, 3, 4 ], "name": "Linhai Yang" }, { "affs": [ 6, 7, 8, 9, 10 ], "name": "Jie Xu" }, { "affs": [ 11, 12, 13, 14, 15 ], "name": "Jun Luo" }, { "affs": [ 16, 17, 18, 19, 20 ], "name": "Yunlong Yu" } ], "bibtex": "https://research.draconitic.com/paper/7ctw767bw4j84.bib", "cited_by": 0, "doi": "10.1186/s12951-026-04841-0", "fulltext_url": "https://europepmc.org/articles/PMC13688791", "id": "7ctw767bw4j84", "issns": [ "1477-3155" ], "landing_url": "https://europepmc.org/article/MED/42919371", "language": "eng", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "lcc", "R855-855.5" ], [ "lcc", "TP248.13-248.65" ], [ "openalex", "2745|Osteoarthritis Treatment and Mechanisms" ] ], "openalex": "W7171448792", "pdf_url": "https://europepmc.org/articles/PMC13688791?pdf=render", "pmcid": "PMC13688791", "pmid": "42919371", "published": "2026-07-01", "publisher": "BMC", "ris": "https://research.draconitic.com/paper/7ctw767bw4j84.ris", "sources": [ { "first_seen": "2026-10-30T12:21:02Z", "native_id": "MED:42919371", "source": "europepmc", "url": "https://europepmc.org/article/MED/42919371" }, { "first_seen": "2026-10-30T13:46:26Z", "native_id": "c7a92af1e6f2462d839d8d95b984c3d8", "source": "doaj", "url": "https://doi.org/10.1186/s12951-026-04841-0" } ], "subjects": [ { "field": "biology", "origin": "lcc:TP248.13-248.65", "subfield": "systems-synthetic" }, { "field": "medicine", "origin": "lcc:R855-855.5", "subfield": "general" } ], "title": "Near-infrared-activated CuTA@PDA@PTH nanozymes remodel the osteoarthritic microenvironment for coordinated cartilage protection and subchondral bone repair.", "title_text": "Near-infrared-activated CuTA@PDA@PTH nanozymes remodel the osteoarthritic microenvironment for coordinated cartilage protection and subchondral bone repair.", "type": "peer-reviewed", "updated_at": "2026-10-30T13:46:26Z", "url": "https://research.draconitic.com/paper/7ctw767bw4j84", "venue": "Journal of nanobiotechnology", "versions": [] }