{
  "abstract": "Introduction: Hypersensitivity reactions to carboplatin include type I reactions, mixed reactions, and delayed reactions.\n\nCase report: We report a case of an atypical cytokine release syndrome induced by carboplatin in a patient with breast carcinoma.\n\nManagement & outcome: The patient developed clinical manifestations consisting of a delayed cytokine release syndrome following administration of carboplatin and paclitaxel. To establish the diagnosis, she underwent a double desensitization protocol over two consecutive days with paclitaxel and carboplatin. A delayed elevation of interleukin-6 after carboplatin supported the diagnosis of an isolated cytokine release syndrome. The patient subsequently continued treatment with paclitaxel through standard infusions and with carboplatin using a desensitization protocol.\n\nDiscussion: Cytokine release syndrome associated with carboplatin has been previously reported as occurring immediately after infusion and as part of a mixed phenotype (type I and cytokine release). A delayed-onset cytokine release syndrome induced by carboplatin, occurring outside the context of a mixed reaction, is reported.\n\nConclusion: Cytokine release syndrome may present as an isolated, delayed reaction following carboplatin infusion. Measurement of interleukin-6 may be a valuable diagnostic tool for confirming the diagnosis of cytokine release syndrome.",
  "abstract_shown": true,
  "affiliations": [
    "Allergy Department, General University Hospital of Castellón, Castellón, Spain",
    "Doctoral School, Jaume I University, Castellon de la Plana, Spain",
    "FISABIO Foundation Research Group, Valencia, Spain",
    "Allergy Department, Castellon Provincial Hospital Consortium, Castellón, Spain",
    "Allergy Department, University Clinical Hospital of Valencia, Valencia, Spain"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Maria Cruz Torres Górriz",
      "orcid": "0009-0005-1859-143X"
    },
    {
      "affs": [
        3
      ],
      "name": "Julian Borrás Cuartero"
    },
    {
      "affs": [
        4
      ],
      "name": "Anna Bosh Requena"
    },
    {
      "affs": [
        0
      ],
      "name": "Dah Tay Jang"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ernesto Enrique"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7d0vd0kyf6sm3.bib",
  "cited_by": 1,
  "doi": "10.1177/03946320261472669",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731877/",
  "id": "7d0vd0kyf6sm3",
  "issns": [
    "0394-6320",
    "2058-7384"
  ],
  "landing_url": "https://doi.org/10.1177/03946320261472669",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Precision Medicine in Immunopathology and Pharmacology"
    ],
    [
      "openalex",
      "2736|Drug-Induced Adverse Reactions"
    ]
  ],
  "openalex": "W7213876846",
  "pdf_url": null,
  "pmcid": "PMC13731877",
  "pmid": "42765956",
  "published": "2026-09-21",
  "publisher": "SAGE Publications",
  "ris": "https://research.draconitic.com/paper/7d0vd0kyf6sm3.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:59Z",
      "native_id": "PMC13731877",
      "source": "pmc",
      "url": "https://doi.org/10.1177/03946320261472669"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Drug-Induced Adverse Reactions",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Atypical cytokine release syndrome induced by carboplatin: The first described case report",
  "title_text": "Atypical cytokine release syndrome induced by carboplatin: The first described case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:59Z",
  "url": "https://research.draconitic.com/paper/7d0vd0kyf6sm3",
  "venue": "International Journal of Immunopathology and Pharmacology",
  "versions": []
}