{ "abstract": "Background\n\nAlthough the Assessment of Different Neoplasias in the adnexa (ADNEX) model has been widely validated, there remains challenges in differentiating true solid components from benign mimics. We aimed to evaluate the feasibility and value of substituting conventional ultrasound-derived solid component size with CEUS-derived measurements in the ADNEX model for adnexal lesions discrimination.Methods\n\nThis multicenter prospective study recruited consecutive patients with suspected adnexal lesions with solid components detected at ultrasound between January 2022 and June 2024. All patients underwent preoperative CEUS examination. Pathological results serve as the reference standard. Each adnexal lesion was evaluated using ADNEX, a CEUS-based modified ADNEX score (CEUS-derived substitution for solid-component measurement without updating model coefficients) and Ovarian-Adnexal Reporting and Data System (O-RADS) Ultrasound (US) score.Results\n\nA total of 204 patients (median age, 47.0 years [IQR: 33.0-56.0 years]) with 204 lesions were included. The area under the receiver operating characteristic curve (AUROC) for CEUS-based modified ADNEX was 0.906 (95% CI: 0.867-0.944), which was superior to that of ADNEX (AUROC:0.865; 95% CI, 0.814-0.916; P = 0.019) and O-RADS US (AUROC: 0.783; 95% CI, 0.726 -0.840; P < 0.001) in classifying adnexal lesions with solid components. CEUS-based modified ADNEX demonstrated greater specificity (0.664) compared to ADNEX (0.283; P < 0.001) and O-RADS US (0.221; P < 0.001).Conclusions\n\nCEUS-derived modification for solid-component measurement in the ADNEX model showed potential improvements in the diagnostic specificity and clinical benefit compared with the original ADNEX framework in the classification of adnexal lesions with solid components.", "abstract_shown": true, "affiliations": [ "Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, People's Republic of China.", "Department of Ultrasound, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China.", "Department of Ultrasound, The Third Hospital of BaoGang Group, The Maternity Hospital of Bao Tou, Baotou, People's Republic of China.", "Department of Ultrasound, Huizhou Central People's Hospital, Huizhou, People's Republic of China.", "Department of Ultrasound, Children's Hospital of Shanxi (Women's Health Center of Shanxi), Taiyuan, People's Republic of China.", "Ultrasound Diagnosis Center, Shaanxi Provincial People's Hospital, Xian, People's Republic of China.", "Department of Ultrasound, The Fifth People's Hospital of Chengdu, Chengdu, People's Republic of China.", "Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.", "Department of Ultrasound, Nanchong Central Hospital, Nanchong, People's Republic of China.", "Department of Ultrasound, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiang'an District, Wuhan, 430014, People's Republic of China. sxf7251@zxhospital.com.", "Department of Ultrasound, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, Guangdong, 510630, People's Republic of China. zhxinl@mail.sysu.edu.cn." ], "article_type": "research article", "arxiv": null, "author_total": 20, "authors": [ { "affs": [ 0 ], "name": "Manli Wu" }, { "affs": [ 0 ], "name": "Ying Chen" }, { "affs": [ 0 ], "name": "Shuangyu Wu" }, { "affs": [ 1 ], "name": "Ruili Wang" }, { "affs": [ 2 ], "name": "Xiaotao Meng" }, { "affs": [ 3 ], "name": "Hong Wen" }, { "affs": [ 4 ], "name": "Rui Zhang" }, { "affs": [ 5 ], "name": "Liang Mu" }, { "affs": [ 6 ], "name": "Li Xiao" }, { "affs": [ 7 ], "name": "Tingting Liu" }, { "affs": [ 8 ], "name": "Sijia Chen" }, { "affs": [ 0 ], "name": "Zeping Huang" }, { "affs": [ 0 ], "name": "Junlin Zhong" }, { "affs": [ 0 ], "name": "Yatong Chen" }, { "affs": [ 0 ], "name": "Ying Wang" }, { "affs": [ 0 ], "name": "Man Zhang" }, { "affs": [ 0 ], "name": "Licong Huang" }, { "affs": [ 0 ], "name": "Jingjing Liu" }, { "affs": [ 9 ], "name": "Xiaofeng Sun" }, { "affs": [ 10 ], "name": "Xinling Zhang", "orcid": "0000-0002-7021-3533" } ], "bibtex": "https://research.draconitic.com/paper/7d1hkepawhaan.bib", "cited_by": 0, "doi": "10.1186/s12905-026-04700-y", "fulltext_url": "https://europepmc.org/articles/PMC13685161", "id": "7d1hkepawhaan", "issns": [ "1472-6874" ], "landing_url": "https://europepmc.org/article/MED/42902302", "language": "eng", "licence": "CC-BY-NC-ND", "licence_label": "CC BY-NC-ND", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "metadata_licence": null, "native_subjects": [ [ "lcc", "RA1-1270" ], [ "lcc", "RG1-991" ], [ "openalex", "2743|Ovarian cancer diagnosis and treatment" ] ], "openalex": "W7170243476", "pdf_url": "https://europepmc.org/articles/PMC13685161?pdf=render", "pmcid": "PMC13685161", "pmid": "42902302", "published": "2026-07-01", "publisher": "BMC", "ris": "https://research.draconitic.com/paper/7d1hkepawhaan.ris", "sources": [ { "first_seen": "2026-10-30T12:19:41Z", "native_id": "MED:42902302", "source": "europepmc", "url": "https://europepmc.org/article/MED/42902302" }, { "first_seen": "2026-10-30T13:46:19Z", "native_id": "24102bd9af2d4ab1ad528ccbbda62550", "source": "doaj", "url": "https://doi.org/10.1186/s12905-026-04700-y" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2743|Ovarian cancer diagnosis and treatment", "subfield": "reproductive-child" } ], "title": "Exploratory evaluation of a CEUS-derived substitution for solid-component measurement in the ADNEX model.", "title_text": "Exploratory evaluation of a CEUS-derived substitution for solid-component measurement in the ADNEX model.", "type": "peer-reviewed", "updated_at": "2026-10-30T13:46:19Z", "url": "https://research.draconitic.com/paper/7d1hkepawhaan", "venue": "BMC women's health", "versions": [] }