{
  "abstract": "Conventional dietary risk metrics such as the Glycemic Index (GI) and Insulinemic Index (II) fail to distinguish between pathological glucose-driven hyperinsulinemia and physiological amino-acid-induced insulin signaling. In particular, ratio-based constructions of insulin-to-glucose responses lead to mathematical singularities and empirical misclassification of metabolically protective foods. We introduce a corrected functional, the Hyperinsulinemic Risk Ratio Prime (HRR), which quantifies time-weighted glyco-insulinemic overlap rather than insulin magnitude alone. The proposed metric is mathematically well-posed, physiologically grounded, and resolves known paradoxes such as the high insulinemic index of fish.",
  "abstract_shown": true,
  "affiliations": [
    "Independent"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "SİNAN İBAGÜNER",
      "orcid": "0000-0001-5221-4359"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7dz7fwma6ve6c.bib",
  "cited_by": 0,
  "doi": "10.13140/rg.2.2.33120.24326",
  "fulltext_url": null,
  "id": "7dz7fwma6ve6c",
  "issns": [],
  "landing_url": "https://zenodo.org/records/23619012",
  "language": null,
  "licence": "CC-BY-SA-4.0",
  "licence_label": "CC BY-SA 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Diabetes, Cardiovascular Risks, and Lipoproteins"
    ]
  ],
  "openalex": "W7223454205",
  "pdf_url": "https://zenodo.org/api/records/23619012/files/HRR%20GT%20RZ.pdf/content",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7dz7fwma6ve6c.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:45Z",
      "native_id": "23619012",
      "source": "zenodo",
      "url": "https://zenodo.org/records/23619012"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Diabetes, Cardiovascular Risks, and Lipoproteins",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "A Corrected Hyperinsulinemic Risk Metric: The Glyco-Insulinemic Risk Ratio Prime (HRR )",
  "title_text": "A Corrected Hyperinsulinemic Risk Metric: The Glyco-Insulinemic Risk Ratio Prime (HRR )",
  "type": "preprint",
  "updated_at": "2026-11-07T12:20:45Z",
  "url": "https://research.draconitic.com/paper/7dz7fwma6ve6c",
  "venue": "Zenodo",
  "versions": []
}