{
  "abstract": "Oxygen availability underpins energy production in multicellular organisms, yet internal oxygen gradients arise in both plants and animals. Plants sense these variations via the plant cysteine oxidase branch of the N-degron pathway, which regulates the stability of key transcription factors. Originally linked to metabolic control, this pathway recently emerged as a development regulator. While the shoot apical meristem was shown to be hypoxic, the oxygen dynamics of organs originating from this low-oxygen niche remain unknown. Here, we show that developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen-sensing machinery. This pathway integrates local oxygen availability to regulate leaf morphogenesis: Early hypoxia restricts cell expansion, whereas subsequent distal-to-proximal oxygenation depletes group VII ethylene response factors enabling specialized cell-fate acquisition and controlling proliferation. Our findings reveal that oxygen acts as a positional cue in normal growth, guiding developmental trajectories. This highlights opportunities to harness oxygen gradients and sensing to direct plant form and function.",
  "abstract_shown": true,
  "affiliations": [
    "Experimental and Computational Plant Development, Institute of Environment Biology, Utrecht University, Utrecht, Netherlands",
    "Department of Biology, University of Oxford, Oxford, UK",
    "School of Biosciences, University of Nottingham, Loughborough LE12 5RD, UK",
    "Plant Stress Resilience, Institute of Environment Biology, Utrecht University, Utrecht, Netherlands",
    "Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gabriele Panicucci",
      "orcid": "0000-0002-7134-3479"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Vinay Shukla",
      "orcid": "0000-0002-7838-8565"
    },
    {
      "affs": [
        0
      ],
      "name": "Viktoriia Voloboeva",
      "orcid": "0000-0002-9372-7414"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Leonardo Jo",
      "orcid": "0000-0001-6514-2913"
    },
    {
      "affs": [
        0
      ],
      "name": "Kees van Kollenburg",
      "orcid": "0009-0004-3986-2780"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Buti",
      "orcid": "0000-0003-4879-2265"
    },
    {
      "affs": [
        1
      ],
      "name": "Laura Dalle Carbonare",
      "orcid": "0000-0002-7536-7654"
    },
    {
      "affs": [
        4
      ],
      "name": "Federico Manuel Giorgi",
      "orcid": "0000-0002-7325-9908"
    },
    {
      "affs": [
        1
      ],
      "name": "Francesco Licausi",
      "orcid": "0000-0003-4769-441X"
    },
    {
      "affs": [
        0
      ],
      "name": "Daan A. Weits",
      "orcid": "0000-0003-4423-5568"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7e01fkv0zfber.bib",
  "cited_by": 5,
  "doi": "10.1126/sciadv.aef2430",
  "fulltext_url": null,
  "id": "7e01fkv0zfber",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://doi.org/10.1126/sciadv.aef2430",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1110|Plant responses to water stress"
    ]
  ],
  "openalex": "W4414401935",
  "pdf_url": null,
  "pmcid": "PMC13524023",
  "pmid": "42664324",
  "published": "2026-08-28",
  "publisher": "American Association for the Advancement of Science",
  "ris": "https://research.draconitic.com/paper/7e01fkv0zfber.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T13:20:51Z",
      "native_id": "W4414401935",
      "source": "openalex",
      "url": "https://doi.org/10.1126/sciadv.aef2430"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Plant responses to water stress",
      "subfield": "plant-biology"
    }
  ],
  "title": "Progressive oxygenation of developing leaves directs morphogenesis",
  "title_text": "Progressive oxygenation of developing leaves directs morphogenesis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:09Z",
  "url": "https://research.draconitic.com/paper/7e01fkv0zfber",
  "venue": "Science Advances",
  "versions": []
}