{
  "abstract": "Post-COVID-19 condition comprises persistent heterogeneous symptoms, and central sensitization-related manifestations may overlap with neurocognitive, autonomic, affective, and functional complaints. This cross-sectional study examined associations between Central Sensitization Inventory (CSI) scores ≥ 40 and persistent clinical manifestations in 153 adults with symptoms after self-reported COVID-19 who attended an outpatient clinic in southern Brazil during 2021–2022. Anxiety, depressive symptoms, sleep quality, functional status, and post-COVID-19 symptoms were assessed. Robust Poisson regression estimated prevalence ratios adjusted for age, sex, education, smoking, body mass index, hypertension and diabetes reported after COVID-19, and hospitalization during acute infection. CSI scores ≥ 40 were observed in 56.2% of participants. In fully adjusted exposure-specific models, elevated CSI scores were associated with brain fog (PR = 1.712; 95% CI 1.185–2.473; p = 0.004), abdominal pain (PR = 1.768; 95% CI 1.206–2.592; p = 0.003), exercise intolerance (PR = 1.533; 95% CI 1.112–2.113; p = 0.009), depressive symptoms (PR = 1.246; 95% CI 1.097–1.416; p = 0.001), and functional limitations (PR = 1.180; 95% CI 1.019–1.368; p = 0.027). Elevated CSI scores were therefore associated with a broad post-COVID-19 symptom profile, although longitudinal studies are needed to clarify temporal direction and determine whether these associations persist across different clinical populations.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Isabela Rezende Ferreira",
      "orcid": "0000-0002-4330-8553"
    },
    {
      "name": "Luciana da Conceição Antunes",
      "orcid": "0000-0002-0106-0721"
    },
    {
      "name": "Júlia Dubois Moreira",
      "orcid": "0000-0002-2256-7222"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7e7gebw7ysh3f.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-72572-1",
  "fulltext_url": null,
  "id": "7e7gebw7ysh3f",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-72572-1",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Long-Term Effects of COVID-19"
    ]
  ],
  "openalex": "W7220693746",
  "pdf_url": "https://www.nature.com/articles/s41598-026-72572-1_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/7e7gebw7ysh3f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.1038/s41598-026-72572-1",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-72572-1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Long-Term Effects of COVID-19",
      "subfield": "neurology"
    }
  ],
  "title": "Elevated central sensitization inventory scores are associated with a multidimensional symptom profile after coronavirus disease 2019",
  "title_text": "Elevated central sensitization inventory scores are associated with a multidimensional symptom profile after coronavirus disease 2019",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/7e7gebw7ysh3f",
  "venue": "Scientific Reports",
  "versions": []
}