{
  "abstract": "The cerebellum is a key node for detecting and adjusting social-prediction internal models. Yet social prediction has been scantly investigated in neurodegenerative cerebellar patients (CB). Thus, we examined CB social-prediction abilities and related cerebellar-cerebral networks, using tailored tasks and resting-state fMRI. Thirteen adult CB and twenty-six matched controls completed three computerized prediction tasks, where contextual priors activate specific internal models setting expectations which may influence recognition of ambiguous targets (emotion expressions, personality-traits, non-social objects). Accuracy and response times were analysed through 2 × 2 × 2 mixed-effects ANOVAs. A congruency index (CI) reflecting whether response was driven by contextual influence was derived from performance efficiency scores and analysed through a 2 × 2 mixed-effects ANOVA. Participants underwent 3T brain MRI, including T1-weighted and resting-state fMRI sequences. Posterior and vermian cerebellar lobules were chosen a-priori as regions of interest and used in a Seed-Based fMRI analysis examining cerebellar-cerebral functional connectivity (FC). FC values from patients' altered connectivity clusters were extracted and correlated with CIs. CB performed worse in the personality-traits task, showing higher reliance on contextual cues. Cerebellar-cerebral underconnectivity was found within networks involved in mentalizing and learning. In CB, higher CI in the personality-traits task, reflecting greater contextual influence and failure to revise behavioural responses, significantly correlated with right lobule VIII-right putamen underconnectivity. These findings indicate reduced flexibility in updating higher-order social predictions when contextual expectations conflict with incoming information, accompanied by altered cerebellar-cerebral FC. Exploratory findings further point to cerebellar-basal ganglia connectivity as a potentially relevant network component of predictive social cognition, warranting further investigation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Human Sciences, Link Campus University, Rome, Italy.",
    "Ataxia Research Laboratory, LIFE - Institute for Research and Health Care - Santa Lucia IRCCS, Rome, Italy.",
    "Department of Psychology, Sapienza University of Rome, Rome, Italy.",
    "IRCCS Mondino Foundation, Pavia, Italy.",
    "Scientific Institute, IRCCS E. Medea, Bosisio Parini, LC, Italy.",
    "Neuroimaging Laboratory, LIFE - Institute for Research and Health Care - Santa Lucia IRCCS, Rome, Italy.",
    "Centro Ricerche Enrico Fermi, Rome, Italy.",
    "Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.",
    "Department of Human and Social Sciences, University of Bergamo, Bergamo, Italy.",
    "Department of Human and Social Sciences, Universitas Mercatorum, Rome, Italy.",
    "Ataxia Research Laboratory, LIFE - Institute for Research and Health Care - Santa Lucia IRCCS, Rome, Italy. maria.leggio@uniroma1.it.",
    "Department of Psychology, Sapienza University of Rome, Rome, Italy. maria.leggio@uniroma1.it."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Libera Siciliano"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Nicole Urbini"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Giusy Olivito"
    },
    {
      "affs": [
        1
      ],
      "name": "Michelle Pisu"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Martina Tanieli"
    },
    {
      "affs": [
        3
      ],
      "name": "Andrea Ciricugno"
    },
    {
      "affs": [
        4
      ],
      "name": "Viola Oldrati"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Federico Giove",
      "orcid": "0000-0002-6934-3146"
    },
    {
      "affs": [
        3,
        7
      ],
      "name": "Renato Borgatti"
    },
    {
      "affs": [
        8
      ],
      "name": "Zaira Cattaneo"
    },
    {
      "affs": [
        4,
        9
      ],
      "name": "Cosimo Urgesi"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Maria Leggio"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7e8m1e6j2je0c.bib",
  "cited_by": 0,
  "doi": "10.1007/s12311-026-02095-y",
  "fulltext_url": "https://europepmc.org/articles/PMC13642411",
  "id": "7e8m1e6j2je0c",
  "issns": [
    "1473-4222",
    "1473-4230"
  ],
  "landing_url": "https://europepmc.org/article/MED/42836925",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|Functional Brain Connectivity Studies"
    ]
  ],
  "openalex": "W7220402767",
  "pdf_url": "https://europepmc.org/articles/PMC13642411?pdf=render",
  "pmcid": "PMC13642411",
  "pmid": "42836925",
  "published": "2026-10-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7e8m1e6j2je0c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:02Z",
      "native_id": "MED:42836925",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42836925"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Functional Brain Connectivity Studies",
      "subfield": "neuroscience"
    }
  ],
  "title": "Large-Scale Cerebellar-Cerebral Network Alterations Underlying Impaired Social Predictive Processing in Cerebellar Neurodegeneration.",
  "title_text": "Large-Scale Cerebellar-Cerebral Network Alterations Underlying Impaired Social Predictive Processing in Cerebellar Neurodegeneration.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:02Z",
  "url": "https://research.draconitic.com/paper/7e8m1e6j2je0c",
  "venue": "Cerebellum (London, England)",
  "versions": []
}