{
  "abstract": "Accurate non-invasive differentiation of basal cell carcinoma (BCC) subtypes is crucial for guiding treatment; however, current imaging tools have limitations in accessibility, depth resolution, and interpretability. To describe sonographic features of distinct BCC subtypes using dermoscopy-guided high-frequency ultrasound (DG-HFUS), and assess its potential as a non-invasive subtyping modality. In this multicenter cross-sectional study, 87 histologically confirmed BCCs (nodular, superficial, infiltrative, and micronodular) were imaged using a portable 33 MHz DG-HFUS device. Morphological features were evaluated independently by blinded observers, and statistical associations with histologic subtypes were analyzed using univariate logistic regression. Hypoechoic mass was the most common sonographic feature of BCCs, seen in 92% of cases. Distinct DG-HFUS features correlated with specific subtypes: ribbon-like shape (OR = 86.3, p < 0.0001), homogeneous internal echoes (OR = 22.5, p = 0.003), and well-defined margins (OR = 9, p = 0.04) were strongly associated with superficial BCC; oval shape (OR = 3.8, p = 0.003) and prominent hyperechoic spots (OR = 3.5, p = 0.005) with nodular BCC; and acoustic shadowing (OR = 7.5, p = 0.001) with infiltrative BCC. Micronodular BCCs were underrepresented. Mixed subtypes were excluded, and vascular patterns were not evaluated. DG-HFUS reveals subtype-specific sonographic features and offers a promising, accessible, and interpretable tool for non-invasive BCC classification in clinical settings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, Venereology and Dermatooncology, Semmelweis University",
    "Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona",
    "Department of Dermatology, Faculty of Medicine, Universidad de Chile",
    "Department of Dermatology, Escuela de Medicina, Pontificia Universidad Catolica de Chile",
    "Departments of Medicine and Dermatology, University of Minnesota",
    "Dermatology Service, Memorial Sloan Kettering Cancer Center",
    "Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles",
    "Department of Dermatology, University Côte d’Azur. Centre Hospitalier Universitaire de Nice (CHU)",
    "Department of Biomedical Engineering, Richard and Loan Hill, University of Illinois at Chicago",
    "Department of Dermatology, Roswell Park Comprehensive Cancer Center"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mehdi Boostani"
    },
    {
      "affs": [
        1
      ],
      "name": "Florencia Vera Morandini"
    },
    {
      "affs": [
        2
      ],
      "name": "Ximena Wortsman"
    },
    {
      "affs": [
        3
      ],
      "name": "Cristian Navarrete-Dechent"
    },
    {
      "affs": [
        1
      ],
      "name": "Javiera Pérez-Anker"
    },
    {
      "affs": [
        1
      ],
      "name": "Priscila Giavedoni"
    },
    {
      "affs": [
        4
      ],
      "name": "Noah Goldfarb"
    },
    {
      "affs": [
        5
      ],
      "name": "Manu Jain"
    },
    {
      "affs": [
        6
      ],
      "name": "Lucas Boussingault"
    },
    {
      "affs": [
        0
      ],
      "name": "Tara Kiss"
    },
    {
      "affs": [
        7
      ],
      "name": "Philippe Bahadoran"
    },
    {
      "affs": [
        8
      ],
      "name": "Kamran Avanaki"
    },
    {
      "affs": [
        0
      ],
      "name": "András Bánvölgyi"
    },
    {
      "affs": [
        0
      ],
      "name": "Kende Lőrincz"
    },
    {
      "affs": [
        0
      ],
      "name": "Norbert M. Wikonkál"
    },
    {
      "affs": [
        6
      ],
      "name": "Veronique Del Marmol"
    },
    {
      "affs": [
        6
      ],
      "name": "Mariano Suppa"
    },
    {
      "affs": [
        1
      ],
      "name": "Josep Malvehy"
    },
    {
      "affs": [
        9
      ],
      "name": "Gyorgy Paragh"
    },
    {
      "affs": [
        0
      ],
      "name": "Norbert Kiss"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7ebm87gk73q96.bib",
  "cited_by": 1,
  "doi": "10.1038/s41598-026-62657-2",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-62657-2",
  "id": "7ebm87gk73q96",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-62657-2",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "2713|Nonmelanoma Skin Cancer Studies"
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  "openalex": "W7170415770",
  "pdf_url": "https://www.nature.com/articles/s41598-026-62657-2_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/7ebm87gk73q96.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:52Z",
      "native_id": "1d4cd7411710455499095fb54d2c3c16",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-62657-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Nonmelanoma Skin Cancer Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Dermoscopy guided high-frequency ultrasound features of basal cell carcinoma subtypes compared with histopathology: a multicenter study",
  "title_text": "Dermoscopy guided high-frequency ultrasound features of basal cell carcinoma subtypes compared with histopathology: a multicenter study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:52Z",
  "url": "https://research.draconitic.com/paper/7ebm87gk73q96",
  "venue": "Scientific Reports",
  "versions": []
}