{
  "abstract": "Crying-triggered pallid and hypotonic episodes in early infancy can be difficult to classify. We report a 44-day-old term female infant with acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who experienced two crying-triggered episodes of marked pallor, limpness, and reduced responsiveness after cessation of crying, followed by spontaneous recovery. Neither event was physiologically recorded, and a definitive cause could not be established. No further episodes were reported during hospitalization or 8 weeks of follow-up. The clinical sequence suggested breath-holding spells (BHS) as one possible explanation alongside infection-associated apnea and other causes of paroxysmal events in early infancy. This case highlights the need for careful differential diagnosis of crying-triggered pallid and hypotonic episodes occurring during acute SARS-CoV-2 infection.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou, Jiangsu, China"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shun Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Sainan Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuqing Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7ebn30wgw7kc5.bib",
  "cited_by": 0,
  "doi": "10.3389/fped.2026.1989655",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13736751/",
  "id": "7ebn30wgw7kc5",
  "issns": [
    "2296-2360"
  ],
  "landing_url": "https://doi.org/10.3389/fped.2026.1989655",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
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      "openalex",
      "2807|Neuroscience of respiration and sleep"
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  "openalex": "W7223185973",
  "pdf_url": "https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2026.1989655/pdf",
  "pmcid": "PMC13736751",
  "pmid": "42991257",
  "published": "2026-10-22",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7ebn30wgw7kc5.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:08Z",
      "native_id": "PMC13736751",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fped.2026.1989655"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2807|Neuroscience of respiration and sleep",
      "subfield": "physiology"
    }
  ],
  "title": "Case Report: Crying-triggered pallid and hypotonic episodes in a 6-week-old infant with SARS-CoV-2 infection—a diagnostic dilemma",
  "title_text": "Case Report: Crying-triggered pallid and hypotonic episodes in a 6-week-old infant with SARS-CoV-2 infection—a diagnostic dilemma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:08Z",
  "url": "https://research.draconitic.com/paper/7ebn30wgw7kc5",
  "venue": "Frontiers in Pediatrics",
  "versions": []
}