{
  "abstract": "Uterine sarcomas represent a rare and heterogeneous group of malignancies whose management remains clinically challenging. They account for approximately 3%–5% of all uterine malignancies. Undifferentiated uterine sarcoma (UUS) is a subtype of uterine sarcomas. SMARCA4 is a tumor suppressor gene that is aberrantly altered in approximately 5%–7% of human malignancies. SMARCA4 -deficient UUS is a highly aggressive, undifferentiated mesenchymal neoplasm associated with a median overall survival (OS) of 7 months. During tumorigenesis, loss of function of either SMARCA4 or SMARCA2 is frequently observed; however, concurrent loss of both genes has been reported to be synthetically lethal and is therefore considered unexpected. In this case report, a 52-year-old Chinese woman with early-stage UUS and SMARCA4 and SMARCA2 co-deficiency underwent surgical resection followed by adjuvant chemotherapy and achieved a disease-free survival (DFS) of 32 months. This case suggests that patients with UUS harboring SMARCA4 and SMARCA2 co-deficiency may derive a survival benefit from early diagnosis and surgical resection. However, owing to the extreme rarity of UUS with co-deficiency of SMARCA4 and SMARCA2 , conducting a high-level phase III randomized controlled trial to validate this observation remains impractical.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Shaoxing Second Hospital, Shaoxing , ,",
    "School of Medicine, Shaoxing University, Shaoxing , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Rong Ji"
    },
    {
      "affs": [
        1
      ],
      "name": "Xialin Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Juan Lang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhongkui Xiong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7ef3hw9ncewjf.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1939651",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671925/?tool=EBI",
  "id": "7ef3hw9ncewjf",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13671925",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|Uterine Myomas and Treatments"
    ]
  ],
  "openalex": "W7215087850",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671925/pdf/?tool=EBI",
  "pmcid": "PMC13671925",
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7ef3hw9ncewjf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:25Z",
      "native_id": "PMC:PMC13671925",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13671925"
    },
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1939651",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1939651/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Uterine Myomas and Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Stage IA undifferentiated uterine sarcoma with SMARCA4 and SMARCA2 co-deficiency: a case report",
  "title_text": "Stage IA undifferentiated uterine sarcoma with SMARCA4 and SMARCA2 co-deficiency: a case report",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:13Z",
  "url": "https://research.draconitic.com/paper/7ef3hw9ncewjf",
  "venue": "Frontiers in oncology",
  "versions": []
}