{
  "abstract": "Objective: To evaluate the efficacy of low-dose dexzopiclone combined with Indirect moxibustion (IM), compared with sham Indirect moxibustion (SIM), on sleep quality (PSQI) and quality of life (SQLS) in patients with schizophrenia and comorbid insomnia.\n\nMethods: This single-center randomized controlled trial (NCT06171308) obtained ethics approval from Shanghai Mental Health Center (SMHC-IRB-2023-08). A total of 120 participants were randomly assigned to the IM group (n = 60) or the SIM group (n = 60), receiving 8 weeks of standardized intervention.\n\nResults: Baseline PSQI and SQLS scores were comparable between the two groups. After 4 and 8 weeks, the IM group demonstrated significantly lower PSQI and SQLS scores than the SIM group (PSQI at week 4: 10.10 ± 1.76 vs. 13.50 ± 1.65, week 8: 10.65 ± 1.54 vs. 12.77 ± 2.05, SQLS at week 4: 28.78 ± 8.84 vs. 35.56 ± 3.38, week 8: 30.36 ± 10.63 vs. 38.07 ± 3.42). The improvement in the IM group was significantly greater than that in the SIM group in terms of change from baseline (PSQI: −3.399 [95% CI: −4.078 to −2.719] at week 4, −2.115 [95% CI: −2.795 to −1.435] at week 8, SQLS: −6.801 [95% CI: −9.104 to −4.462] at week 4, −7.732 [95% CI: −10.071 to −5.393] at week 8), with all adjusted intergroup differences being statistically significant (P < 0.001).\n\nConclusions: Adjunctive Indirect Moxibustion led to statistically significant and clinically meaningful improvements in sleep quality and quality of life compared to sham procedure in this patient population over an 8-week period. These preliminary findings suggest IM is a promising adjunctive therapy. Further multicenter, long-term trials with expanded outcome indicators are required to validate its generalizability and sustained efficacy.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13063-026-09915-w.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Traditional Chinese Medicine for Mental Health, Shanghai, People’s Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jing Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Mei Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianming Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7ej0gr8gg1as9.bib",
  "cited_by": 0,
  "doi": "10.1186/s13063-026-09915-w",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13700130/",
  "id": "7ej0gr8gg1as9",
  "issns": [
    "1745-6215"
  ],
  "landing_url": "https://doi.org/10.1186/s13063-026-09915-w",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "3205|Sleep and related disorders"
    ]
  ],
  "openalex": "W7171495698",
  "pdf_url": "https://europepmc.org/articles/PMC13700130?pdf=render",
  "pmcid": "PMC13700130",
  "pmid": "42928360",
  "published": "2026-07-29",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/7ej0gr8gg1as9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:38Z",
      "native_id": "PMC13700130",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13063-026-09915-w"
    },
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928360",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928360"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1745-6215",
      "subfield": "clinical-trials"
    }
  ],
  "title": "Indirect moxibustion therapy improves insomnia and associated symptoms in patients with schizophrenia",
  "title_text": "Indirect moxibustion therapy improves insomnia and associated symptoms in patients with schizophrenia",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:36:35Z",
  "url": "https://research.draconitic.com/paper/7ej0gr8gg1as9",
  "venue": "Trials",
  "versions": []
}