{
  "abstract": "Thyroid eye disease (TED), also historically referred to as thyroid-associated ophthalmopathy (TAO) or Graves' orbitopathy (GO), is an autoimmune ophthalmopathy characterized by inflammation and adipogenesis within orbital adipose (OA) tissue. While the contribution of immune cell infiltration and fibroblast activation is recognized, the cellular heterogeneity and the potential role of local microbial dysbiosis in the orbital microenvironment remain poorly defined. Here, we present a multi-omics dataset derived from OA of patients with TED and healthy controls collected at Beijing Tongren Hospital. The dataset comprises single-cell RNA sequencing (scRNA-seq) data generated from human orbital adipose tissue and subcutaneous fat. Following quality control filtering and doublet removal, a total of 61,302 high-quality singlet cells were retained for downstream analyses, capturing the transcriptomic landscape of orbital fibroblasts, immune subsets, and vascular cells. In parallel, 16S rRNA gene sequencing was performed on orbital adipose tissue samples collected from the integrated study cohort, alongside environmental samples for contamination assessment, to characterize the low-biomass orbital microbiome DNA signatures. Raw sequencing reads, quality-controlled gene-expression matrices, and contamination-corrected microbial feature tables are provided. Our dataset provides an opportunity to investigate the crosstalk between host cellular immunity and potential local microbiome signatures, facilitating hypothesis generation regarding host-microbiome crosstalk and the exploration of novel therapeutic targets for TED.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.",
    "International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China.",
    "Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.",
    "Department of Ophthalmology, Air Force Medical Center, Beijing, 100142, China.",
    "Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China.",
    "Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn.",
    "International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn.",
    "Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn.",
    "Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com.",
    "Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiang Xu"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Fei Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Weiqi Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Haowen Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yingyu Wang"
    },
    {
      "affs": [
        0,
        1,
        4
      ],
      "name": "Yuan Li"
    },
    {
      "affs": [
        0,
        1,
        4
      ],
      "name": "Bing Wang"
    },
    {
      "affs": [
        5,
        6,
        7
      ],
      "name": "Mingming Liu"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Yang Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7eseharrbntsp.bib",
  "cited_by": 0,
  "doi": "10.1038/s41597-026-08064-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13680605",
  "id": "7eseharrbntsp",
  "issns": [
    "2052-4463"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897260",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Ophthalmology and Eye Disorders"
    ]
  ],
  "openalex": "W7202399269",
  "pdf_url": "https://europepmc.org/articles/PMC13680605?pdf=render",
  "pmcid": "PMC13680605",
  "pmid": "42897260",
  "published": "2026-08-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7eseharrbntsp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42897260",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897260"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Ophthalmology and Eye Disorders",
      "subfield": "general"
    }
  ],
  "title": "An integrated single-cell transcriptomic and microbiome dataset of orbital adipose tissue in thyroid eye disease.",
  "title_text": "An integrated single-cell transcriptomic and microbiome dataset of orbital adipose tissue in thyroid eye disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/7eseharrbntsp",
  "venue": "Scientific data",
  "versions": []
}