{
  "abstract": "目的探究血清程序性细胞死亡因子4（Programmed Cell Death Protein 4，PDCD4）、血管紧张素转化酶2（Angiotensin-Converting Enzyme 2，ACE2）与轻症社区获得性肺炎（Community-Acquired Pneumonia，CAP）患者肺通气功能的关系。方法选取2022年10月至2024年7月来郑州大学附属郑州中心医院治疗的124例轻症CAP患者为患病组，另选同期124例体检健康者为对照组。比较血清中PDCD4、ACE2的水平；采用Pearson法分析血清PDCD4、ACE2水平与肺通气功能的相关性；多因素Logistic回归分析轻症CAP的影响因素；ROC曲线分析血清PDCD4、ACE2水平对轻症CAP的诊断价值。结果与对照组相比，患病组患者的年龄、BMI、血钠以及性别、吸烟史、饮酒史、糖尿病、高血压差异无统计学意义（P>0.05），患者血清CRP、WBC水平均明显升高（P<0.05）；与对照组相比，患病组血清PDCD4、ACE2水平均明显降低（P<0.05）；与对照组相比，患病组肺通气功能相关指标FVC、FEV1、PEF水平均明显降低（P<0.05）；血清PDCD4、ACE2水平与肺通气功能相关指标FVC、FEV1、PEF水平均为正相关（P<0.05）；CRP、WBC、PDCD4、ACE2均为轻症CAP的影响因素（P<0.05）；血清PDCD4、ACE2水平诊断轻症CAP的曲线下面积（AUC）分别为0.756、0.809，二者联合诊断的AUC为0.880，二者联合诊断的AUC明显高于各指标单独诊断（Z二者联合-PDCD4=4.231、Z二者联合-ACE2=3.563，P=0.000、0.000），二者联合诊断的敏感度为89.52%，特异性为72.58%。结论轻症CAP患者血清PDCD4、ACE2水平均明显下调，血清PDCD4、ACE2水平与肺通气功能相关，且均为轻症CAP的影响因素，二者联合检测对轻症CAP具有较高的诊断价值。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "杨玲萍"
    },
    {
      "name": "李凤娟"
    },
    {
      "name": "张华"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7f7w5xm2b3786.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.005",
  "id": "7f7w5xm2b3786",
  "issns": [
    "1007-4287"
  ],
  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.005",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/7f7w5xm2b3786.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:46Z",
      "native_id": "962eae762c1449a58e25d8878b93d485",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.005"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "血清PDCD4、ACE2与轻症社区获得性肺炎患者肺通气功能的关系",
  "title_text": "血清PDCD4、ACE2与轻症社区获得性肺炎患者肺通气功能的关系",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:46Z",
  "url": "https://research.draconitic.com/paper/7f7w5xm2b3786",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}