{
  "abstract": "This study presents an efficient and environmentally sustainable technique for extracting flavonoids from Artemisia argyi folium, employing natural deep eutectic solvents combined with ultrasound-assisted extraction (NADESs-UAE). Among the ten DES systems evaluated, the Choline Chloride-Lactic Acid mixture (ChCl-LA, molar ratio 1:1, designated as DES-3) yielded the highest extraction of 93.39 mg of rutin equivalents (RE) per gram of dry weight (DW). This was much higher than the yields obtained with traditional 60% ethanol or water extraction methods. Response surface methodology (RSM) was used to optimize key extraction variables, including water content, extraction time, temperature, and liquid-to-solid ratio. Optimal conditions included 51.5 g/100 g water content, 56 min extraction time, and an extraction temperature of 59 °C. The liquid-to-solid ratio reached 48 mL/g under optimized conditions. Under these conditions, the predicted flavonoid yield was 99.27 mg RE/g DW, whereas the experimental value was 98.71 ± 0.66 mg RE/g DW, confirming the model's reliability. Kinetic investigations demonstrated that the extraction process followed a pseudo-second-order kinetic model, indicating enhanced diffusion-assisted mass transfer under ultrasonic cavitation conditions. Scanning electron microscopy (SEM) analysis revealed that DES-3 induced pronounced cellular disruption, thereby facilitating enhanced flavonoid extraction. Fourier-transform infrared (FT-IR) spectroscopy further confirmed the presence of strong hydrogen-bonding interactions between ChCl-LA and flavonoid compounds. Compared with conventional solvent systems, the ChCl-LA extract exhibited superior antioxidant activity, including DPPH radical-scavenging activity (959.98 ± 9.59 mg Trolox/g DW), as well as enhanced α-glucosidase inhibition (91.8% at 125 μg/mL) and antibacterial activity. Furthermore, treatment with AAF extracts effectively improved strawberry firmness and enhanced POD activity during storage, thereby prolonging strawberry shelf life. Overall, the findings demonstrate that NADESs-UAE represents a promising green extraction strategy for the efficient recovery and practical utilization of flavonoids from Artemisia argyi folium.",
  "abstract_shown": true,
  "affiliations": [
    "School of Biological and Food Engineering, Suzhou University, Suzhou 234000, China; Collaborative Technology Service Center for the High-Value Processing of Green Agricultural Products (Prepared Foods) in the Yangtze River Delta Region, Suzhou University, Suzhou 234000, China. Electronic address: ninabao@ahszu.edu.cn",
    "School of Biological and Food Engineering, Suzhou University, Suzhou 234000, China; College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China",
    "School of Biological and Food Engineering, Suzhou University, Suzhou 234000, China; Collaborative Technology Service Center for the High-Value Processing of Green Agricultural Products (Prepared Foods) in the Yangtze River Delta Region, Suzhou University, Suzhou 234000, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nina Bao"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinyuan Zhao",
      "orcid": "0000-0003-2388-5967"
    },
    {
      "affs": [
        2
      ],
      "name": "Lele Li",
      "orcid": "0000-0001-8593-9292"
    },
    {
      "affs": [
        2
      ],
      "name": "Marwan M. A. Rashed"
    },
    {
      "affs": [
        2
      ],
      "name": "Weifeng Yuan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7frsrvmcpwr4h.bib",
  "cited_by": 5,
  "doi": "10.1016/j.ultsonch.2026.107952",
  "fulltext_url": null,
  "id": "7frsrvmcpwr4h",
  "issns": [
    "1350-4177",
    "1873-2828"
  ],
  "landing_url": "https://doi.org/10.1016/j.ultsonch.2026.107952",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1606|Ionic liquids properties and applications"
    ]
  ],
  "openalex": "W7167611505",
  "pdf_url": null,
  "pmcid": "PMC13380774",
  "pmid": "42435645",
  "published": "2026-07-07",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/7frsrvmcpwr4h.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T13:20:46Z",
      "native_id": "W7167611505",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.ultsonch.2026.107952"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1606|Ionic liquids properties and applications",
      "subfield": "physical"
    }
  ],
  "title": "Ultrasound-assisted extraction of flavonoids from Artemisia argyi folium using deep eutectic solvents: optimization, mechanistic characterization, bioactivity evaluation, and strawberry preservation applications",
  "title_text": "Ultrasound-assisted extraction of flavonoids from Artemisia argyi folium using deep eutectic solvents: optimization, mechanistic characterization, bioactivity evaluation, and strawberry preservation applications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:39Z",
  "url": "https://research.draconitic.com/paper/7frsrvmcpwr4h",
  "venue": "Ultrasonics Sonochemistry",
  "versions": []
}