{
  "abstract": "Myogenic differentiation is a complex and tightly regulated process involving multiple transcriptional regulators. KDM5A (lysine demethylase 5A) is a histone demethylase that regulates gene transcription and has been implicated in skeletal muscle differentiation. In Inclusion Body Myositis, we previously associated dysregulated myogenic differentiation with KDM5A overactivity. Immortalised human myoblasts overexpressing KDM5A showed an altered transcriptional landscape, with differential expression of key myogenic differentiation factors and significantly increased expression of sarcomeric genes. Although no morphological differences were observed, KDM5A-overexpressing myotubes showed a higher proportion of myogenin-positive nuclei during late-stage differentiation, suggesting that KDM5A modulates myogenic differentiation dynamics.",
  "abstract_shown": true,
  "affiliations": [
    "Translational Neurosciences and Peripheral Neuropathy Group, UAntwerp, Antwerp, VLG, BE.",
    "Laboratory of Neuromuscular Pathology, Institute Born-Bunge, UAntwerp, Antwerp, VLG, BE.",
    "Peripheral Neuropathy Research Group, Department of Biomedical Sciences, UAntwerp, Antwerp, VLG, BE.",
    "Department of Neurology, Neuromuscular Reference Centre, Antwerp UH, Antwerp, VLG, BE."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Geert de Vries"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alice Monticelli"
    },
    {
      "affs": [
        2
      ],
      "name": "Vicky De Winter"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Danique Beijer"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Willem De Ridder"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Jonathan Baets"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7fw8tezna7ex7.bib",
  "cited_by": 0,
  "doi": "10.17912/micropub.biology.002136",
  "fulltext_url": "https://europepmc.org/articles/PMC13688108",
  "id": "7fw8tezna7ex7",
  "issns": [
    "2578-9430"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923842",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Muscle Physiology and Disorders"
    ]
  ],
  "openalex": "W7221005969",
  "pdf_url": "https://europepmc.org/articles/PMC13688108?pdf=render",
  "pmcid": "PMC13688108",
  "pmid": "42923842",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7fw8tezna7ex7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923842",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923842"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Muscle Physiology and Disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "KDM5A overexpression modulates key myogenic differentiation factors and sarcomere gene expression.",
  "title_text": "KDM5A overexpression modulates key myogenic differentiation factors and sarcomere gene expression.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/7fw8tezna7ex7",
  "venue": "MicroPublication biology",
  "versions": []
}