{
  "abstract": "Cerebral venous sinus thrombosis (CVST) and carotid web (CW) are distinct cerebrovascular disorders where vascular geometry, disturbed hemodynamics, and endothelial activation interact to drive thrombosis. Both conditions disproportionately affect women, yet remain understudied because of the inability of traditional platforms to replicate complex three-dimensional lumen profiles. This perspective positions light-based lithography as a powerful biofabrication strategy for patient-specific modeling. Digital light processing and volumetric bioprinting render enclosed, perfusable hydrogel networks with high-fidelity surface topography. When integrated into dynamic vessel-on-chip perfusion loops guided by clinical imaging and computational fluid dynamics, these platforms simulate pathological flow stasis and recirculation zones, heterogeneous shear-stress gradients, and site-specific cellular aggregation. This biofabrication approach enables personalized disease modeling and translationally relevant risk assessment, providing a critical platform for advancing women's cerebrovascular health.",
  "abstract_shown": true,
  "affiliations": [
    "School of Biomedical Engineering, The University of Sydney, Darlington, NSW 2008, Australia.",
    "Charles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.",
    "The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, Camperdown, NSW 2006, Australia.",
    "Heart Research Institute, Camperdown, Newtown, NSW 2042, Australia.",
    "Centre for Peripheral Artery Disease, Heart Research Institute, Newtown, NSW 2042, Australia.",
    "School of Medical Sciences, The University of Sydney, Camperdown, NSW 2006, Australia.",
    "School of Electrical and Mechanical Engineering, Institute for Photonics and Advanced Sensing (IPAS), Adelaide University, Adelaide, SA 5000, Australia.",
    "School of Biomedical Engineering, University of Technology Sydney, Ultimo, NSW 2007, Australia.",
    "Department of Surgery, University of Toronto; Division of Neurosurgery & SickKids Research Institute, The Hospital for Sick Children, Toronto M5G 1X8, Canada.",
    "Department of Engineering, University of Cambridge, Cambridge CB2 1PZ, UK.",
    "The Nanoscience Centre, University of Cambridge, Cambridge CB3 0FF, UK.",
    "Sydney Biomanufacturing Incubator, The University of Sydney, Camperdown, NSW 2006, Australia.",
    "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.",
    "Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.",
    "Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Linda Dei-Awuku",
      "orcid": "0009-0000-4444-9852"
    },
    {
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        0,
        2
      ],
      "name": "Nicole A. Yap"
    },
    {
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        1,
        2,
        3
      ],
      "name": "Yunduo Charles Zhao",
      "orcid": "0000-0002-1802-2318"
    },
    {
      "affs": [
        0
      ],
      "name": "Zihao Wang",
      "orcid": "0000-0002-9971-4358"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Mary M. Kavurma",
      "orcid": "0000-0001-7353-0932"
    },
    {
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        6
      ],
      "name": "Jiawen Li",
      "orcid": "0000-0001-8818-6070"
    },
    {
      "affs": [
        7
      ],
      "name": "Xiaoxue Xu",
      "orcid": "0000-0002-2598-3766"
    },
    {
      "affs": [
        8
      ],
      "name": "Jennifer Quon",
      "orcid": "0000-0003-1202-5881"
    },
    {
      "affs": [
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        10
      ],
      "name": "Yan Yan S. Huang",
      "orcid": "0000-0003-2619-730X"
    },
    {
      "affs": [
        1,
        2,
        5,
        11
      ],
      "name": "Khoon S. Lim",
      "orcid": "0000-0002-2486-196X"
    },
    {
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        12,
        13,
        14
      ],
      "name": "Kim-Lien Nguyen",
      "orcid": "0000-0002-8854-2976"
    },
    {
      "affs": [
        12,
        13
      ],
      "name": "Tzung K. Hsiai",
      "orcid": "0000-0003-1734-0792"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Lining Arnold Ju",
      "orcid": "0000-0002-7591-0864"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7g171gktess5h.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aeh3952",
  "fulltext_url": null,
  "id": "7g171gktess5h",
  "issns": [
    "2375-2548"
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  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aeh3952",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|3D Printing in Biomedical Research"
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  "openalex": "W7215733295",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/7g171gktess5h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aeh3952",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aeh3952"
    }
  ],
  "subjects": [],
  "title": "Engineering neurovascular thrombosis: Light-based bioprinting for patient-specific modeling and women’s cerebrovascular health",
  "title_text": "Engineering neurovascular thrombosis: Light-based bioprinting for patient-specific modeling and women’s cerebrovascular health",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:41Z",
  "url": "https://research.draconitic.com/paper/7g171gktess5h",
  "venue": "Science Advances",
  "versions": []
}