{
  "abstract": "Intravascular large B-cell lymphoma (IVLBCL) is a rare and aggressive subtype of extranodal non-Hodgkin lymphoma (NHL) that typically involves the central nervous system (CNS) and skin in its classic (Western) variant and frequently presents with systemic B-symptoms. We present a rare case of IVLBCL in a 59-year-old female with cutaneous-only involvement, no B-symptoms, and negative PET-CT. The patient's initial presentation mimicked inflammatory conditions, contributing to diagnostic delay. Deep skin biopsy was crucial and confirmed the diagnosis of IVLBCL. PET-CT was non-revealing, showing limitations in cutaneous-dominant disease. The patient underwent R-CHOP treatment along with CNS prophylaxis, achieving complete remission with no relapse at follow-up. This case emphasizes the importance of high suspicion and early biopsy in atypical cutaneous presentations and the need for personalized strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology and Oncohematology, Louis Pasteur University Hospital, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia.",
    "Department of Radiotherapy and Oncology, East Slovakia Institute of Oncology, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia.",
    "Department of Clinical Immunology and Allergology, Louis Pasteur University Hospital and OKIA s.r.o, Košice, Slovakia.",
    "Department of Pathology, Louis Pasteur University Hospital, Košice, Slovakia.",
    "Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia.",
    "Faculty of Medicine, Pavol Jozef Šafárik University and OKIA s.r.o, Košice, Slovakia.",
    "Department of Cardiology, Kardiocentrum AGEL-Šaca a.s., Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovakia."
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Juliana Gabzdilova"
    },
    {
      "affs": [
        1
      ],
      "name": "Atila David Homolya"
    },
    {
      "affs": [
        2
      ],
      "name": "Stefan Raffac"
    },
    {
      "affs": [
        3
      ],
      "name": "Frantisek Gmitter"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomas Guman"
    },
    {
      "affs": [
        4
      ],
      "name": "Viktoria Hazikova"
    },
    {
      "affs": [
        5
      ],
      "name": "Martina Maria Raffacova"
    },
    {
      "affs": [
        6
      ],
      "name": "Filip Breznen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7g6a56qwgxkvf.bib",
  "cited_by": 0,
  "doi": "10.1016/j.lrr.2026.100619",
  "fulltext_url": "https://europepmc.org/articles/PMC13717087",
  "id": "7g6a56qwgxkvf",
  "issns": [
    "2213-0489"
  ],
  "landing_url": "https://europepmc.org/article/MED/42959444",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2728|CNS Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222849022",
  "pdf_url": "https://europepmc.org/articles/PMC13717087?pdf=render",
  "pmcid": "PMC13717087",
  "pmid": "42959444",
  "published": "2026-10-17",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/7g6a56qwgxkvf.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42959444",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959444"
    },
    {
      "first_seen": "2026-11-02T12:21:28Z",
      "native_id": "PMC13717087",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.lrr.2026.100619"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|CNS Lymphoma Diagnosis and Treatment",
      "subfield": "neurology"
    }
  ],
  "title": "Intravascular large B-cell lymphoma (IVLBCL) presenting with exclusive cutaneous involvement, no B-symptoms and negative PET-CT: A Case Study.",
  "title_text": "Intravascular large B-cell lymphoma (IVLBCL) presenting with exclusive cutaneous involvement, no B-symptoms and negative PET-CT: A Case Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:28Z",
  "url": "https://research.draconitic.com/paper/7g6a56qwgxkvf",
  "venue": "Leukemia research reports",
  "versions": []
}