{
  "abstract": "This prospective single-center cohort study evaluated changes in serum levels of novel adipokines and myokines, including isthmin-1 and irisin, as well as the advanced glycation end product (AGE)–soluble receptor for AGE (sRAGE) axis and monomeric C-reactive protein (mCRP) in patients with obesity before and 5 months after laparoscopic sleeve gastrectomy (LSG). The study included 38 patients with obesity (26 females and 12 males) with a median age of 42 years who underwent LSG. Laboratory parameters were assessed using commercially available immunoenzymatic assays. We observed a significant decrease in isthmin-1 concentration at the postoperative time point (Me = 2.10 ng/mL vs. Me = 1.93 ng/mL, p = 0.009). Moreover, a significant increase in irisin levels (Me = 7.33 µg/mL vs. Me = 10.64 µg/mL, p = 0.002) and AGEs (Me = 589.50 ng/mL vs. Me = 698.60 ng/mL, p = 0.015) was observed after LSG. A significant increase in AGE levels was also noted after normalization to total protein (Me = 8.34 ng/mg protein vs. Me = 10.37 ng/mg protein, p = 0.027). sRAGE levels were similar at both time points. Five months after LSG, mCRP levels were significantly lower (Me = 1.99 ng/mL vs. Me = 1.55 ng/mL, p = 0.020). Exploratory correlation analyses identified potential associations between AGEs and isthmin-1 (R = 0.37) and between sRAGE and irisin (R = −0.31) preoperatively. Five months after LSG, potential associations were observed between AGEs and irisin (R = 0.38) and between sRAGE and mCRP (R = −0.37). Our findings indicate a decrease in circulating isthmin-1 and mCRP, together with an increase in irisin and AGE concentrations following LSG, suggesting changes in selected metabolic and tissue-related biomarkers after surgery. Further studies are needed to determine the mechanisms underlying these changes and to clarify their potential clinical significance.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General, Gastroenterological, and Oncological Surgery, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland",
    "Pathophysiology Department, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland",
    "Department of Hematology and Oncology, National Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, Poland"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wojciech Kupczyk"
    },
    {
      "affs": [
        1
      ],
      "name": "Joanna Boinska"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Artur Słomka",
      "orcid": "0000-0002-4137-2981"
    },
    {
      "affs": [
        0
      ],
      "name": "Kinga Kupczyk"
    },
    {
      "affs": [
        0
      ],
      "name": "Marek Jackowski"
    },
    {
      "affs": [
        1
      ],
      "name": "Ewa Żekanowska"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7g86myfg67xj3.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198932",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666223/?tool=EBI",
  "id": "7g86myfg67xj3",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13666223",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Bariatric Surgery and Outcomes"
    ]
  ],
  "openalex": "W7221190770",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666223/pdf/?tool=EBI",
  "pmcid": "PMC13666223",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7g86myfg67xj3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "PMC:PMC13666223",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13666223"
    },
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27198932",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/19/8932"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Bariatric Surgery and Outcomes",
      "subfield": "surgery"
    }
  ],
  "title": "Changes in Isthmin-1, Irisin, and the AGE–RAGE Axis Following LSG: A Prospective Single-Center Cohort Study",
  "title_text": "Changes in Isthmin-1, Irisin, and the AGE–RAGE Axis Following LSG: A Prospective Single-Center Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:55Z",
  "url": "https://research.draconitic.com/paper/7g86myfg67xj3",
  "venue": "International journal of molecular sciences",
  "versions": []
}