{
  "abstract": "Skeletal editing is rapidly reshaping synthetic chemistry by enabling precise, atom-level modifications to complex molecular frameworks. Despite recent advances in methodology development, skeletal editing has yet to realize its full impact on complex molecule synthesis. In this Perspective, we highlight the power of single-atom skeletal editing transformations in enabling efficient syntheses of various complex natural products and advocate for the development of new methods and novel applications. We present guidelines rooted in historical precedent along with modern case studies that highlight when skeletal edits enable efficient synthesis, and where reactivity gaps still limit broader adoption. By analyzing the existing literature, we aim to inspire novel retrosynthetic disconnections, and steer new method development, which, collectively, will advance the fields of total synthesis and skeletal editing.",
  "abstract_shown": true,
  "affiliations": [
    "Emory University , , , ,",
    "University of California , , , ,"
  ],
  "article_type": "review",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Reem Al-Ahmad",
      "orcid": "0000-0001-7591-3371"
    },
    {
      "affs": [
        1
      ],
      "name": "Isabel de la Torre Roehl",
      "orcid": "0009-0001-4181-1876"
    },
    {
      "affs": [
        0
      ],
      "name": "Chang Liu",
      "orcid": "0000-0001-7100-9983"
    },
    {
      "affs": [
        1
      ],
      "name": "Richmond Sarpong",
      "orcid": "0000-0002-0028-6323"
    },
    {
      "affs": [
        0
      ],
      "name": "Mingji Dai",
      "orcid": "0000-0001-7956-6426"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7gf30m4m554ht.bib",
  "cited_by": 14,
  "doi": "10.1021/jacs.6c04423",
  "fulltext_url": null,
  "id": "7gf30m4m554ht",
  "issns": [
    "0002-7863",
    "1520-5126",
    "1943-2984"
  ],
  "landing_url": "https://doi.org/10.1021/jacs.6c04423",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Advanced Synthetic Organic Chemistry"
    ]
  ],
  "openalex": "W7162140998",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/jacs.6c04423?ref=article_openPDF",
  "pmcid": "PMC13244438",
  "pmid": "42169556",
  "published": "2026-05-22",
  "publisher": "American Chemical Society",
  "ris": "https://research.draconitic.com/paper/7gf30m4m554ht.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:44Z",
      "native_id": "W7162140998",
      "source": "openalex",
      "url": "https://doi.org/10.1021/jacs.6c04423"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Advanced Synthetic Organic Chemistry",
      "subfield": "organic"
    }
  ],
  "title": "Strategic Applications of Single-Atom Skeletal Editing in Natural Product Synthesis",
  "title_text": "Strategic Applications of Single-Atom Skeletal Editing in Natural Product Synthesis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T13:21:03Z",
  "url": "https://research.draconitic.com/paper/7gf30m4m554ht",
  "venue": "Journal of the American Chemical Society",
  "versions": []
}