{
  "abstract": "We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Laetitia Mony"
    },
    {
      "name": "Nicolas Triballeau"
    },
    {
      "name": "Pierre Paoletti"
    },
    {
      "name": "Francine Acher"
    },
    {
      "name": "Hugues-Olivier Bertrand"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7gg47hhnmyskx.bib",
  "cited_by": 12,
  "doi": "10.1016/j.bmcl.2010.07.043",
  "fulltext_url": null,
  "id": "7gg47hhnmyskx",
  "issns": [
    "0960-894X"
  ],
  "landing_url": "https://hal.science/hal-05773222v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "hal",
      "1.sdv.sp"
    ],
    [
      "hal",
      "2.sdv.neu.nb"
    ],
    [
      "hal",
      "2.sdv.sp.pharma"
    ],
    [
      "openalex",
      "1703|Computational Drug Discovery Methods"
    ]
  ],
  "openalex": "W2136417005",
  "pdf_url": "https://hal.science/hal-05773222/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/7gg47hhnmyskx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:45Z",
      "native_id": "hal-05773222",
      "source": "hal",
      "url": "https://hal.science/hal-05773222v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.neu",
      "subfield": "neuroscience"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.sp",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach",
  "title_text": "Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:45Z",
  "url": "https://research.draconitic.com/paper/7gg47hhnmyskx",
  "venue": "Bioorganic and Medicinal Chemistry Letters",
  "versions": []
}