{
  "abstract": "Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty, mainly caused by bacterial biofilm formation and antibiotic resistance. Traditional static surfaces rely on contact killing-based bactericidal properties and cannot reliably clear mature biofilms. In this study, we fabricate a remote-activated dynamic biomimetic system, namely a movable magnetic topographic surface (MMTS). Here we show that under the exposure of external electromagnetic field (EMF), the anchored Janus nano-heterodimers oscillate periodically to mechanically disrupt bacterial membranes and eradicates biofilms of Staphylococcus aureus and Escherichia coli. This mechanical force can also activates Piezo1 mechanosensitive ion channel in bone marrow mesenchymal stem cells (BMSCs), inducing calcium oscillations, upregulating gene expression of Runx2 and BMP2, and enhancing extracellular matrix mineralization. In vivo, MMTS combined with EMF exposure eliminates local infection and promoted osseointegration. This remote-activated dynamic biomimetic strategy offers a promising multifunctional platform for PJI treatment, and improved implant osteointegration in clinical orthopedics.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Yangmengfan Chen"
    },
    {
      "name": "Hao Du"
    },
    {
      "name": "Heng Sun"
    },
    {
      "name": "Xingcan Huang"
    },
    {
      "name": "Duan Wang"
    },
    {
      "name": "Xuming Chen"
    },
    {
      "name": "Jiehao Chen"
    },
    {
      "name": "Xuanjun Zhang",
      "orcid": "0000-0001-6452-1778"
    },
    {
      "name": "Liqiang Zhou",
      "orcid": "0000-0002-1184-4036"
    },
    {
      "name": "Zongke Zhou",
      "orcid": "0000-0002-9037-4756"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7ghmpz0g0p5bg.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78462-4",
  "fulltext_url": "https://europepmc.org/articles/PMC13680427",
  "id": "7ghmpz0g0p5bg",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-78462-4",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Orthopedic Infections and Treatments"
    ]
  ],
  "openalex": "W7222966954",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78462-4.pdf",
  "pmcid": "PMC13680427",
  "pmid": "42897207",
  "published": "2026-10-19",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/7ghmpz0g0p5bg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-78462-4",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-78462-4"
    },
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42897207",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897207"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Orthopedic Infections and Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling",
  "title_text": "Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/7ghmpz0g0p5bg",
  "venue": "Nature Communications",
  "versions": []
}