{
  "abstract": "Visual dysfunction and depressive symptoms are common and often disabling manifestations of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). In this multicenter cross-sectional study, 458 adults with MS ( n = 370) or NMOSD ( n = 88) were recruited from six tertiary hospitals in China. Vision-related quality of life (VRQoL) was assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25), depressive symptoms using the Hospital Anxiety and Depression Scale depression subscale (HADS-D), and objective visual impairment using World Health Organization blindness criteria. Lower NEI VFQ-25 scores were associated with HADS-D screen positivity after adjustment for measured covariates (OR 2.33 per 10-point decrease, 95% CI 1.81–3.00; p < 0.001), whereas WHO-defined blindness was not significantly associated with HADS-D screen positivity in the fully adjusted model. In domain-specific analyses, associations for Core Visual Function were attenuated after mutual adjustment, whereas Psychosocial scores remained associated with HADS-D screen positivity. These cross-sectional findings suggest that vision-related patient-reported outcomes capture aspects of functional and psychosocial disease burden that are not fully reflected by a binary classification of visual impairment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Xianyang Hospital of Yan'an University",
    "Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University",
    "Department of Neurology, General Hospital of Ningxia Medical University",
    "Department of Neurology, The Second Hospital of Lanzhou University",
    "Department of Neurology, The First Affiliated Hospital of Shanxi Medical University",
    "Department of Neurology, Qinghai University Affiliated Hospital",
    "Department of Neurology, The First Affiliated Hospital of Harbin Medical University",
    "Department of Psychology, The University of Hong Kong"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Guoxun Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Han Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaojia Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Yu Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Chunyang Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Xiao Yang"
    },
    {
      "affs": [
        3
      ],
      "name": "Jia Guo"
    },
    {
      "affs": [
        4
      ],
      "name": "Huaxing Meng"
    },
    {
      "affs": [
        5
      ],
      "name": "Xuelan Ye"
    },
    {
      "affs": [
        6
      ],
      "name": "Di Zhong"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongmei Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yanru He"
    },
    {
      "affs": [
        1
      ],
      "name": "Dongjie Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Jinting Zhu"
    },
    {
      "affs": [
        1
      ],
      "name": "Lili Ge"
    },
    {
      "affs": [
        1
      ],
      "name": "Qiwu Zhou"
    },
    {
      "affs": [
        7
      ],
      "name": "Kin Chiu"
    },
    {
      "affs": [
        1
      ],
      "name": "Runze Zhao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7gmpq4bw0s6t2.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1975600",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727409/?tool=EBI",
  "id": "7gmpq4bw0s6t2",
  "issns": [
    "1664-2295"
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  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1975600/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2734|Multiple Sclerosis Research Studies"
    ]
  ],
  "openalex": "W7223014857",
  "pdf_url": "https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1975600/pdf",
  "pmcid": "PMC13727409",
  "pmid": "42978592",
  "published": "2026-10-20",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7gmpq4bw0s6t2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:16Z",
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      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1975600/full"
    },
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      "url": "https://doi.org/10.3389/fneur.2026.1975600"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2295",
      "subfield": "neurology"
    }
  ],
  "title": "Association between psychosocial consequences of visual dysfunction and depressive symptom burden in multiple sclerosis and neuromyelitis optica spectrum disorder",
  "title_text": "Association between psychosocial consequences of visual dysfunction and depressive symptom burden in multiple sclerosis and neuromyelitis optica spectrum disorder",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:36Z",
  "url": "https://research.draconitic.com/paper/7gmpq4bw0s6t2",
  "venue": "Frontiers in Neurology",
  "versions": []
}