{
  "abstract": "ObjectiveThe objectives of this study were to examine racial differences and temporal trends in Alzheimers disease (AD)- and Parkinsons disease (PD)-related mortality among U.S. adults and to assess whether racial mortality patterns and temporal changes differed.\n\nMethodsWe analyzed CDC WONDER Multiple Cause of Death data from 2018-2024, where mortality was defined as deaths with AD or PD recorded as an underlying or contributing cause. Age-standardized mortality rates and adjusted mortality rate ratios (MRRs) were estimated. Joint-point regression evaluated racial differences, annual percentage changes (APCs), and disease-race-year interactions. Sensitivity analyses assessed the robustness of the findings.\n\nResultsBlack had significantly lower PD-related mortality than White (adjusted mortality rate ratios [MRRs]: 0.62-0.69; all p<0.001), whereas AD-related mortality showed no significant racial differences (MRRs: 0.91-1.06). Compared with 2018, mortality increased significantly in 2020 for both diseases among White adults (AD: MRR=1.21; PD: MRR=1.27) and Black adults (AD: MRR=1.27; PD: MRR=1.37), followed by partial declines. PD-related mortality increased significantly among White adults during 2018-2023 (annual percentage change [APC]=3.08%; 95% CI: 1.15%-5.05%), whereas trends among Black adults (APC=3.51%; 95% CI: -2.94% to 10.39%) and AD-related mortality trends in both racial groups were not statistically significant. The disease-race-year interaction was not significant (p=0.942), indicating insufficient evidence that temporal mortality patterns differed jointly.\n\nConclusionsRecorded PD-related mortality was lower among Black than White adults, whereas AD-related mortality showed no statistically significant racial difference. These findings support disease-specific mortality surveillance and further investigation of potential differences in diagnostic recognition and death-certificate documentation.",
  "abstract_shown": true,
  "affiliations": [
    "University ofSouth Florida"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "M. R. Ahmmad"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7gwjb8pmzjvry.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.22.26366001",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.22.26366001v1.full",
  "id": "7gwjb8pmzjvry",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.22.26366001v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "neurology"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7223473979",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.22.26366001v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7gwjb8pmzjvry.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:38Z",
      "native_id": "10.64898/2026.10.22.26366001",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.22.26366001v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Racial Disparities and Trends in Alzheimers and Parkinsons Disease-Related Mortality: A CDC WONDER Study 2018-2024",
  "title_text": "Racial Disparities and Trends in Alzheimers and Parkinsons Disease-Related Mortality: A CDC WONDER Study 2018-2024",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:38Z",
  "url": "https://research.draconitic.com/paper/7gwjb8pmzjvry",
  "venue": "medRxiv",
  "versions": []
}