{
  "abstract": "BACKGROUND AND PURPOSE: Complications of aneurysmal SAH (aSAH), including vasospasm and delayed cerebral ischemia (DCI), substantially contribute to morbidity and mortality. We investigated the correlation between quantitative measurements on MRA performed immediately after endovascular embolization and subsequent development of DCI or vasospasm. MATERIALS AND METHODS: We included consecutive patients scanned between September 1, 2016 and January 14, 2022 with ruptured intracranial aneurysms (IAs) after endovascular treatment. We recorded clinical data including sex, age, body mass index (BMI), smoking history, vascular risk factors, baseline CTA/CT features, modified Fisher score, and Glasgow Coma Score. We extracted quantitative MRA features, including total arterial length, total branch number, and average tortuosity, using a custom semiautomated software (VesselVoyager). Correlations among baseline quantitative MRA and other imaging and clinical features with DCI and vasospasm were determined using logistic regression analysis. Receiver operating characteristic (ROC) curves were calculated for clinical-only models and for models augmented with quantitative MRA features. RESULTS: = .02) were independently associated with vasospasm incidence on multivariable regression. Adding quantitative MRA features improved ROC performance for both DCI (area under the receiver operating characteristic curve 0.63 [95% CI, 0.51-0.75]) vs 0.75 [95% CI, 0.64-0.87]) and vasospasm (area under the receiver operating characteristic curve 0.67 [95% CI, 0.54-0.79] vs 0.85 [95% CI, 0.77-0.94]). CONCLUSIONS: In patients with aSAH, average tortuosity is independently inversely associated with future development of DCI. Total branch number and average tortuosity are independently inversely associated with future vasospasm. With further validation, quantitative MRA features may serve as predictive markers for DCI and vasospasm after aSAH.",
  "abstract_shown": true,
  "affiliations": [
    "From the Department of Radiology (M.H.M., M.K., M.A., C.W., D.C., M.R.L., G.C., C.Y., N.B., M.M.-B.), University of Washington, Seattle, Washington",
    "Department of Radiology (M.A.), University of Colorado, Aurora, Colorado",
    "Department of Bioengineering (K.Z.), University of Washington, Seattle, Washington",
    "Department of Neurosurgery (M.R.L.), University of Washington, Seattle, Washington",
    "Department of Mechanical Engineering (M.R.L.), University of Washington, Seattle, Washington",
    "Department of Radiology (M.M.-B.), University of Alabama at Birmingham, Birmingham, Alabama"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mohamad H. Mosi",
      "orcid": "0009-0007-4406-6393"
    },
    {
      "affs": [
        0
      ],
      "name": "Mona Kharaji"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mehmet Aksakal",
      "orcid": "0000-0002-2381-2058"
    },
    {
      "affs": [
        2
      ],
      "name": "Kaiyu Zhang",
      "orcid": "0000-0001-7208-3114"
    },
    {
      "affs": [
        0
      ],
      "name": "Charles Watt"
    },
    {
      "affs": [
        0
      ],
      "name": "Dan Cheng"
    },
    {
      "affs": [
        0,
        3,
        4
      ],
      "name": "Michael R. Levitt",
      "orcid": "0000-0003-3612-3347"
    },
    {
      "affs": [
        0
      ],
      "name": "Gador Canton",
      "orcid": "0000-0002-0594-2764"
    },
    {
      "affs": [
        0
      ],
      "name": "Chun Yuan",
      "orcid": "0000-0002-6154-5106"
    },
    {
      "affs": [
        0
      ],
      "name": "Niranjan Balu",
      "orcid": "0000-0002-1489-6683"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Mahmud Mossa-Basha",
      "orcid": "0000-0001-7798-8158"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7h62qcm4231na.bib",
  "cited_by": 0,
  "doi": "10.3174/ajnr.a9303",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738308/",
  "id": "7h62qcm4231na",
  "issns": [
    "0195-6108",
    "1936-959X"
  ],
  "landing_url": "https://doi.org/10.3174/ajnr.a9303",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Editor's Choice"
    ],
    [
      "heading",
      "Neurovascular/Stroke Imaging"
    ],
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2728|Intracranial Aneurysms: Treatment and Complications"
    ]
  ],
  "openalex": "W7139919951",
  "pdf_url": null,
  "pmcid": "PMC13738308",
  "pmid": "41862188",
  "published": "2026-11-06",
  "publisher": "American Society of Neuroradiology",
  "ris": "https://research.draconitic.com/paper/7h62qcm4231na.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:19Z",
      "native_id": "PMC13738308",
      "source": "pmc",
      "url": "https://doi.org/10.3174/ajnr.a9303"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracranial Aneurysms: Treatment and Complications",
      "subfield": "neurology"
    }
  ],
  "title": "Quantitative MRA Feature Prediction of Postaneurysmal Subarachnoid Hemorrhage Delayed Cerebral Ischemia and Angiographic Vasospasm",
  "title_text": "Quantitative MRA Feature Prediction of Postaneurysmal Subarachnoid Hemorrhage Delayed Cerebral Ischemia and Angiographic Vasospasm",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:19Z",
  "url": "https://research.draconitic.com/paper/7h62qcm4231na",
  "venue": "AJNR: American Journal of Neuroradiology",
  "versions": []
}