{
  "abstract": "Background: Prostatic abscess caused by carbapenem-resistant Escherichia coli (CREC) is an uncommon but serious infection with limited therapeutic options, particularly when prolonged antimicrobial therapy and oral step-down treatment are required. Evidence supporting fosfomycin monotherapy for prostatic abscess caused by CREC remains scarce.\n\nCase Summary: A 67-year-old man with diabetes mellitus and prolonged corticosteroid exposure presented with severe sepsis secondary to a multiloculated prostatic abscess measuring 57.2 × 38.7 × 49.4 mm. Urine and abscess cultures yielded KPC-producing CREC susceptible to fosfomycin (MIC = 0.25 μg/mL) and amikacin. Because access to newer β-lactam/β-lactamase inhibitor agents was limited, treatment was initiated with intravenous fosfomycin plus amikacin. Amikacin was discontinued after 2 days because of nephrotoxicity, and therapy was successfully continued with intravenous fosfomycin monotherapy following transperineal ultrasound-guided abscess drainage. The patient received intravenous fosfomycin 6 g every 8 h for 21 days, followed by oral fosfomycin calcium 3 g every 24 h for 30 days, with complete clinical and radiological resolution, and no relapse during 6 months of follow-up.\n\nConclusion: Although the initial brief course of amikacin may have contributed to early bacterial clearance, the majority of treatment was administered as fosfomycin monotherapy after adequate source control. This case suggests that antibiotic susceptibility test-guided fosfomycin monotherapy, combined with adequate drainage, is a feasible treatment for prostatic abscesses caused by CREC, particularly in resource-limited settings.",
  "abstract_shown": true,
  "affiliations": [
    "Vietnamese-German Center for Medical Research (VG-CARE), 108 Military Central Hospital, Hanoi, Vietnam",
    "Institute of Clinical Infectious Diseases, 108 Military Central Hospital, Hanoi, Vietnam",
    "Department of Functional Exploration, 108 Military Central Hospital, Hanoi, Vietnam"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Nguyen Thi Tuyen"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nguyen Sy Thau",
      "orcid": "0000-0002-9335-6211"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Pham Thi Thanh Nhan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nguyen Van Tuan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nguyen Trong The",
      "orcid": "0000-0002-5433-7712"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7h8mccn29n89r.bib",
  "cited_by": 0,
  "doi": "10.1128/asmcr.00112-26",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729746/?tool=EBI",
  "id": "7h8mccn29n89r",
  "issns": [
    "2996-2684"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729746",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Infectious Disease Case Reports"
    ],
    [
      "openalex",
      "2748|Urinary Tract Infections Management"
    ]
  ],
  "openalex": "W7213302467",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729746/pdf/?tool=EBI",
  "pmcid": "PMC13729746",
  "pmid": "42979430",
  "published": "2026-09-15",
  "publisher": "American Society for Microbiology (ASM)",
  "ris": "https://research.draconitic.com/paper/7h8mccn29n89r.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:45Z",
      "native_id": "PMC:PMC13729746",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729746"
    },
    {
      "first_seen": "2026-11-07T12:22:29Z",
      "native_id": "PMC13729746",
      "source": "pmc",
      "url": "https://doi.org/10.1128/asmcr.00112-26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2748|Urinary Tract Infections Management",
      "subfield": "general"
    }
  ],
  "title": "Fosfomycin monotherapy for the treatment of a complicated prostatic abscess caused by KPC-producing carbapenem-resistant Escherichia coli",
  "title_text": "Fosfomycin monotherapy for the treatment of a complicated prostatic abscess caused by KPC-producing carbapenem-resistant Escherichia coli",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:29Z",
  "url": "https://research.draconitic.com/paper/7h8mccn29n89r",
  "venue": "ASM case reports",
  "versions": []
}