{
  "abstract": "BACKGROUND: -adrenergic agonist, may induce relaxation of gastrointestinal smooth muscle. OBJECTIVE: To evaluate the efficacy of inhaled salbutamol versus placebo for the treatment of moderate-to-severe IgE-mediated abdominal pain reactions. METHODS: This randomized, double-blind, placebo-controlled trial enrolled patients aged 6 years to 55 years or less who developed moderate-to-severe abdominal pain during an oral food challenge or oral immunotherapy dose administration. Participants were randomized (1:1) to receive 800 μg of inhaled salbutamol or placebo. Participants self-reported pain intensity at 1-minute intervals for 30 minutes using the Numerical Rating Scale. The primary outcome was time to patient-perceived adequate analgesia. RESULTS: Twenty-four participants (median age, 11.5 years, 37.5% females) were randomized at a single center. The median time to patient-perceived adequate analgesia was 6.0 minutes in the salbutamol group and was not reached by 30 minutes in the placebo group (hazard ratio, 0.35; 95% CI, 0.12-0.99; P = .034). The median time to complete resolution of abdominal pain was 10.0 minutes with salbutamol and was not reached by 30 minutes in the placebo group (hazard ratio, 0.33; 95% CI, 0.12-0.92; P = .027). The trial was terminated early because of changes in clinical practice resulting in slower-than-expected recruitment. CONCLUSIONS: In this prematurely terminated randomized trial, inhaled salbutamol was associated with faster relief from IgE-mediated, food allergy-related abdominal pain compared with placebo. These findings require confirmation in a larger, multicenter study.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 32,
  "authors": [
    {
      "name": "Camille Braun"
    },
    {
      "name": "Eloïse Antony"
    },
    {
      "name": "Marie-Lee Simard"
    },
    {
      "name": "Kathryn Samaan"
    },
    {
      "name": "François Graham"
    },
    {
      "name": "Florence Gingras-Lessard"
    },
    {
      "name": "Roxane Labrosse"
    },
    {
      "name": "Louis Paradis"
    },
    {
      "name": "Anne Des Roches"
    },
    {
      "name": "Philippe Bégin"
    },
    {
      "name": "Samina Ali"
    },
    {
      "name": "Waleed Alqurashi"
    },
    {
      "name": "Aikaterini Anagnostou"
    },
    {
      "name": "Stefania Arasi"
    },
    {
      "name": "Moshe Ben-Shoshan"
    },
    {
      "name": "Marie-Josée Bettez"
    },
    {
      "name": "R. Sharon Chinthrajah"
    },
    {
      "name": "Raoul Daoust"
    },
    {
      "name": "Abigail Davis"
    },
    {
      "name": "Thomas Eiwegger"
    },
    {
      "name": "Mohamed Eltorki"
    },
    {
      "name": "David Fleischer"
    },
    {
      "name": "Edwin Kim"
    },
    {
      "name": "Jocelyn Gravel"
    },
    {
      "name": "Jennifer Gerdts"
    },
    {
      "name": "Matthew Greenhawt"
    },
    {
      "name": "Guillaume Lezmi"
    },
    {
      "name": "Douglas Mack"
    },
    {
      "name": "Thomas Poder"
    },
    {
      "name": "Paul Turner"
    },
    {
      "name": "Julia Upton"
    },
    {
      "name": "Matthieu Vincent"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7hc137b37f1eg.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jaip.2026.05.036",
  "fulltext_url": null,
  "id": "7hc137b37f1eg",
  "issns": [
    "2213-2198",
    "2213-2201"
  ],
  "landing_url": "https://hal.science/hal-05795488v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.imm"
    ],
    [
      "hal",
      "2.sdv.imm.all"
    ],
    [
      "openalex",
      "2723|Food Allergy and Anaphylaxis Research"
    ]
  ],
  "openalex": "W7164919967",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": "Elsevier / American Academy of Allergy, Asthma & Immunology / American Academy of Allergy, Asthma and Immunology",
  "ris": "https://research.draconitic.com/paper/7hc137b37f1eg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:55Z",
      "native_id": "hal-05795488",
      "source": "hal",
      "url": "https://hal.science/hal-05795488v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    }
  ],
  "title": "Inhaled Salbutamol Versus Placebo for the Treatment of Acute IgE-Mediated Abdominal Pain From Allergic Food Reactions (INSPIRE Trial): A Double-Blind Randomized Trial",
  "title_text": "Inhaled Salbutamol Versus Placebo for the Treatment of Acute IgE-Mediated Abdominal Pain From Allergic Food Reactions (INSPIRE Trial): A Double-Blind Randomized Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:55Z",
  "url": "https://research.draconitic.com/paper/7hc137b37f1eg",
  "venue": "Journal of Allergy and Clinical Immunology: In Practice",
  "versions": []
}