{
  "abstract": "ObjectivesTo evaluate the impact of COVID-19 vaccination on the prevention of long COVID (LC) in the Omicron era through an updated systematic review and meta-analysis.\n\nMethodsWe performed an update of our previously published systematic review and meta-analysis of vaccination and LC risk (searches between 1 January 2022 and 1 March 2024). Databases (Embase, MEDLINE, PubMed, Europe PMC, LILACS, Cochrane COVID-19 Study Register) were searched for studies published between 1 March 2024 and 13 July 2026.\n\nObservational studies assessing the impact of vaccination on the risk of LC four or more weeks after SARS-CoV-2 infection were included. Vaccines were restricted to those centrally authorised in the European Union. Random-effects meta-analyses, restricted to adults, were performed to calculate pooled odds ratios (OR) of LC in three comparisons: vaccinated (any dose) versus unvaccinated; booster vaccination versus unvaccinated; and booster vaccination versus primary course vaccination only.\n\nResultsNineteen new studies were identified, of which ten were included in the updated meta-analyses alongside eight studies from the original review. The pooled OR of LC in vaccinated adults (any dose) versus unvaccinated was 0.75 (95% confidence interval [CI] 0.67-0.84; 13 studies). ORs were also lower for booster vaccination versus unvaccinated (0.73; 95% CI 0.65-0.82; 6 studies), and booster vaccination versus primary course vaccination (0.63; 95% CI 0.53-0.75; 6 studies). Significant associations between vaccination and lower LC odds were observed in subgroup analyses of mRNA-only vaccination and LC outcomes three or more months after infection.\n\nConclusionsThis updated review and meta-analysis reinforces our previous finding that vaccination may reduce the burden of LC in the Omicron era, with booster doses potentially providing additional protection. Although evidence in high-risk groups now prioritised for vaccination in most countries remains limited, these findings clearly demonstrate the benefits of vaccination and support current seasonal vaccination strategies.",
  "abstract_shown": true,
  "affiliations": [
    "BioNTech UK Ltd"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Z. Marjenberg"
    },
    {
      "name": "M. J. Peluso"
    },
    {
      "name": "E. Wynberg"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Abduljawad"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7hvc73z6yx323.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.12.26365288",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.12.26365288v1.full",
  "id": "7hvc73z6yx323",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.12.26365288v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "infectious diseases"
    ],
    [
      "openalex",
      "2728|Long-Term Effects of COVID-19"
    ]
  ],
  "openalex": "W7221688729",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.12.26365288v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7hvc73z6yx323.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:45Z",
      "native_id": "10.64898/2026.10.12.26365288",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.12.26365288v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:infectious diseases",
      "subfield": "infectious-disease"
    }
  ],
  "title": "The impact of COVID-19 vaccination on long COVID prevention in the Omicron era: An updated systematic review and meta-analysis",
  "title_text": "The impact of COVID-19 vaccination on long COVID prevention in the Omicron era: An updated systematic review and meta-analysis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:45Z",
  "url": "https://research.draconitic.com/paper/7hvc73z6yx323",
  "venue": "medRxiv",
  "versions": []
}