{
  "abstract": "DNA methylation modulates transcription factor (TF) binding, and plays an important role in regulating gene expression. We developed methylTFR, an R package for quantifying TF activity from DNA methylation across TF-binding sites, providing a low-dimensional and interpretable activity profile. Across 147 human immune cell methylomes, methylTFR identified cell-type-specific regulators, including CEBP and ETS family activity in myeloid cells. In CD4+ T cells, TF activity scores resolved the naive-to-memory trajectory and highlighted AP-1 factors as important memory regulators. We applied methylTFR to sparse single-cell methylome data, and we integrated derived activity scores with gene expression and accessibility into joint factor models yielding multimodal views of lineage regulators.",
  "abstract_shown": true,
  "affiliations": [
    "Saarland University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "I. B. Gunduz"
    },
    {
      "name": "R. Nitsch"
    },
    {
      "name": "S. K. Murugan"
    },
    {
      "affs": [
        0
      ],
      "name": "F. Mueller"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7hzmd9xccf6rf.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.29.755279",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755279v1.full",
  "id": "7hzmd9xccf6rf",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755279v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "1312|Epigenetics and DNA Methylation"
    ]
  ],
  "openalex": "W7220368803",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755279v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7hzmd9xccf6rf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:02Z",
      "native_id": "10.64898/2026.09.29.755279",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755279v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "methylTFR: Computational quantification of transcription factor activity from DNA methylation",
  "title_text": "methylTFR: Computational quantification of transcription factor activity from DNA methylation",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:02Z",
  "url": "https://research.draconitic.com/paper/7hzmd9xccf6rf",
  "venue": "bioRxiv",
  "versions": []
}