{
  "abstract": "T-cell acute lymphoblastic leukemia (T-ALL) accounts for one of the most aggressive hematological tumors associated with poor prognosis, notably for relapsed and refractory patients. Hence, an unmet medical need persists for T-ALL patients who fail to durably respond to conventional treatments. Herein, we report the antileukemic efficacy of anti-thymocyte globulin (ATG), a polyclonal cocktail of IgG enriched in antibodies directed against human thymocyte antigens. The treatment of preclinical models of T-ALL reveals a cytotoxic mechanism of ATG mediated by TNFα signaling. We demonstrate that ATG resistance may occur via the induction of negative regulators of TNFα-induced cell death and can be circumvented by SMAC mimetic birinapant ex vivo and in vivo. These results are validated in a series of prospective primary relapsed/refractory T-ALL samples. Here, we provide a strong rationale for clinically relevant ATG-based immunotherapy in combination with birinapant to treat T-ALL patients.",
  "abstract_shown": true,
  "affiliations": [
    "Université de Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris, France.",
    "Université de Paris Cité, Department of Pediatric Hematology and Immunology, Robert Debré University Hospital (AP-HP), Paris, France.",
    "AP-HP, Hôpital Saint Louis, Unité d'Hématologie, Paris, France.",
    "Department of Pediatric Hematology and Oncology, Assistance Publique-Hôpitaux de Paris (AP-HP), GH HUEP, Armand Trousseau Hospital, Paris, France and Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CDR Saint-Antoine, GRC n°07, GRC MyPAC, Paris, France.",
    "PRES LUNAM, CHU Angers service des Maladies du Sang et CRCINA INSERM, Angers, France.",
    "Université de Paris, Institut de Recherche Saint-Louis, Paris, France.",
    "INSERM, U1163, Institut Imagine, Paris, France.",
    "AP-HP, Hôpital Saint Louis, Unité d'Hématologie Adolescents et Jeunes Adultes, Paris, France.",
    "Institut Curie, UMR3348, Orsay, France, CNRS UMR3348, Centre Universitaire, Orsay, University Paris-Saclay, Orsay, France.",
    "Service d'Hématologie - Centre Hospitalier de Versailles et U1184, CEA, Université Versailles Paris Saclay, Le Chesnay, France.",
    "Université de Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris, France. guillaume.andrieu@inserm.fr.",
    "Université de Paris Cité, Institut Necker-Enfants Malades (INEM), Institut national de la santé et de la recherche médicale (Inserm) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris, France. vahid.asnafi@aphp.fr."
  ],
  "article_type": "research support, non u.s. gov't",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Marie Emilie Dourthe"
    },
    {
      "affs": [
        0
      ],
      "name": "Mehdi Latiri",
      "orcid": "0009-0005-1520-4633"
    },
    {
      "affs": [
        2
      ],
      "name": "Etienne Lengliné"
    },
    {
      "affs": [
        0
      ],
      "name": "Guillaume Charbonnier"
    },
    {
      "affs": [
        0
      ],
      "name": "Chaimae Saji"
    },
    {
      "affs": [
        0
      ],
      "name": "Grégoire Huré"
    },
    {
      "affs": [
        0
      ],
      "name": "Camille Gillet"
    },
    {
      "affs": [
        0
      ],
      "name": "Jérôme Doss"
    },
    {
      "affs": [
        0
      ],
      "name": "Aurore Touzart",
      "orcid": "0000-0002-8888-2292"
    },
    {
      "affs": [
        0
      ],
      "name": "Lucien Courtois"
    },
    {
      "affs": [
        0
      ],
      "name": "Agata Cieslak",
      "orcid": "0000-0003-1015-9448"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Mathieu Simonin",
      "orcid": "0000-0002-0448-8811"
    },
    {
      "affs": [
        4
      ],
      "name": "Norbert Ifrah"
    },
    {
      "affs": [
        5
      ],
      "name": "Hervé Dombret"
    },
    {
      "affs": [
        6
      ],
      "name": "Olivier Hermine"
    },
    {
      "affs": [
        5,
        7
      ],
      "name": "Nicolas Boissel",
      "orcid": "0000-0003-2091-7927"
    },
    {
      "affs": [
        1,
        5
      ],
      "name": "André Baruchel"
    },
    {
      "affs": [
        8
      ],
      "name": "Jacques Ghysdael"
    },
    {
      "affs": [
        0
      ],
      "name": "Elizabeth Macintyre",
      "orcid": "0000-0003-0520-0493"
    },
    {
      "affs": [
        9
      ],
      "name": "Philippe Rousselot"
    },
    {
      "affs": [
        8
      ],
      "name": "Christine Tran Quang",
      "orcid": "0000-0002-1003-2626"
    },
    {
      "affs": [
        10
      ],
      "name": "Guillaume P Andrieu"
    },
    {
      "affs": [
        11
      ],
      "name": "Vahid Asnafi",
      "orcid": "0000-0002-6255-5314"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7j5ja5pcsesey.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77027-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13683388",
  "id": "7j5ja5pcsesey",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://europepmc.org/article/MED/42901909",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Acute Lymphoblastic Leukemia research"
    ]
  ],
  "openalex": "W7213636142",
  "pdf_url": "https://europepmc.org/articles/PMC13683388?pdf=render",
  "pmcid": "PMC13683388",
  "pmid": "42901909",
  "published": "2026-09-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7j5ja5pcsesey.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:41Z",
      "native_id": "MED:42901909",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42901909"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Acute Lymphoblastic Leukemia research",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Anti-thymocyte globulin triggers TNF-dependent cell death in T-cell acute lymphoblastic leukemia.",
  "title_text": "Anti-thymocyte globulin triggers TNF-dependent cell death in T-cell acute lymphoblastic leukemia.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:41Z",
  "url": "https://research.draconitic.com/paper/7j5ja5pcsesey",
  "venue": "Nature communications",
  "versions": []
}