{
  "abstract": "We report the generation and characterization of a human induced pluripotent stem cell (iPSC) line derived from dermal fibroblasts of a patient with Skogholt disease, a rare maternally inherited neurodegenerative syndrome associated with choroid plexus dysfunction and impaired cerebrospinal fluid (CSF) homeostasis. Patient fibroblasts were reprogrammed using the non-integrating Repro-OSKGM kit. The resulting iPSC line exhibited typical pluripotent morphology, expressed canonical pluripotency markers, maintained a normal karyotype, retained the disease-associated genetic variant, was mycoplasma-free, and demonstrated trilineage differentiation potential. We also made choroid plexus (ChP) like organoids from the generated iPSCs. This patient-specific iPSC line provides a valuable resource for generating choroid plexus organoids and neurons to investigate disease mechanisms and develop therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "University of Oslo, Ahus Campus"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "W. Przybyla"
    },
    {
      "name": "S. Gupta"
    },
    {
      "name": "H. B. Fjerdingstad"
    },
    {
      "name": "P. Selnes"
    },
    {
      "affs": [
        0
      ],
      "name": "K. Sharma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7jd0yr19af7v1.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.29.747981",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.08.29.747981v1.full",
  "id": "7jd0yr19af7v1",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.08.29.747981v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cell biology"
    ],
    [
      "openalex",
      "1312|Pluripotent Stem Cells Research"
    ]
  ],
  "openalex": "W7204754303",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.08.29.747981v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7jd0yr19af7v1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:30Z",
      "native_id": "10.64898/2026.08.29.747981",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.08.29.747981v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "Generation and characterization of a patient-specific human induced pluripotent stem cell line from a Skogholt syndrome patient (ASCFi003-A)",
  "title_text": "Generation and characterization of a patient-specific human induced pluripotent stem cell line from a Skogholt syndrome patient (ASCFi003-A)",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:30Z",
  "url": "https://research.draconitic.com/paper/7jd0yr19af7v1",
  "venue": "bioRxiv",
  "versions": []
}