{
  "abstract": "Background: Vascular endothelial growth factor inhibitors (VEGFi) play an integral role in the treatment of gynecologic malignancies. However, a common limitation to treatment is hypertension, a known adverse effect of VEGFi. Patients requiring prolonged treatment with VEGFi carry a higher cardiovascular risk.\n\nProject Rationale: There is no standardized, prospective pathway to manage VEGFi-associated hypertension and keep cancer therapy on schedule, particularly in gynecologic oncology patients with prolonged therapy and comorbidities.\n\nProject Summary: We implemented a prospective, nonrandomized, and protocol-driven pilot quality improvement study enrolling 22 patients with gynecologic malignancies who were initiating or receiving VEGFi therapy. Management included mechanism-based antihypertensive therapy, grant-funded home blood pressure monitoring, structured education, and multidisciplinary follow-up. No patient had hypertension-related interruptions to VEGFi therapy, and most achieved control with 1 to 2 agents.\n\nTake-Home Message: A multidisciplinary cardio-oncology pathway successfully prevented hypertension-related VEGFi treatment interruptions while emphasizing the importance of addressing broader cardiovascular comorbidities beyond hypertension alone.",
  "abstract_shown": true,
  "affiliations": [
    "Northside Hospital Gwinnett Internal Medicine Residency Program, Lawrenceville, Georgia, USA",
    "Northside Hospital Heart Institute (NHHI), Northside Hospital, Atlanta, Georgia, USA",
    "University Gynecologic Oncology, Northside Hospital, Atlanta, Georgia, USA",
    "Northside Hospital Cancer Institute (NHCI), Northside Hospital, Atlanta, Georgia, USA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pragnya Tatikonda"
    },
    {
      "affs": [
        1
      ],
      "name": "Lalitha C. Medepalli"
    },
    {
      "affs": [
        0
      ],
      "name": "Christopher N. Cooper"
    },
    {
      "affs": [
        2
      ],
      "name": "Guilherme Cantuaria"
    },
    {
      "affs": [
        2
      ],
      "name": "Oi Wah Stephanie Yap"
    },
    {
      "affs": [
        2
      ],
      "name": "Meaghan Tenney"
    },
    {
      "affs": [
        2
      ],
      "name": "Jackie Wojno"
    },
    {
      "affs": [
        3
      ],
      "name": "Christina M. Berry"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7jfxdp8t7vqfc.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jaccas.2026.109398",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13728311/",
  "id": "7jfxdp8t7vqfc",
  "issns": [
    "2666-0849"
  ],
  "landing_url": "https://doi.org/10.1016/j.jaccas.2026.109398",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cardio-Oncology"
    ],
    [
      "heading",
      "Quality Improvement Projects"
    ],
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
    ]
  ],
  "openalex": "W7213415116",
  "pdf_url": "https://www.jacc.org/doi/pdf/10.1016/j.jaccas.2026.109398?download=true",
  "pmcid": "PMC13728311",
  "pmid": "42752042",
  "published": "2026-09-16",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/7jfxdp8t7vqfc.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:24:01Z",
      "native_id": "PMC13728311",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jaccas.2026.109398"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Community-Based Cardio-Oncology Model for Hypertension Management in Gynecologic Oncology Patients on VEGF Inhibitors",
  "title_text": "Community-Based Cardio-Oncology Model for Hypertension Management in Gynecologic Oncology Patients on VEGF Inhibitors",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:19Z",
  "url": "https://research.draconitic.com/paper/7jfxdp8t7vqfc",
  "venue": "JACC Case Reports",
  "versions": []
}