{
  "abstract": "Objective: To compare survival of patients with different histological types of locally advanced cervical cancer after treatment with radical surgery or radical radiotherapy. Methods: Data for United States residents diagnosed with locally advanced cervical cancer between 2000 and 2022 were extracted from the Surveillance, Epidemiology, and End Results database. Overall survival and cancer-specific survival were compared using multivariable Cox proportional hazards regression. To minimize baseline differences, patients from each group were paired using propensity score matching. Results: Among the 1,363 patients with squamous cell carcinoma in the propensity score-matched cohort, surgery was associated with significantly better overall survival when disease was in stage IB3 (HR 0.70, 95% CI 0.50–0.97), but not when it was in other stages. Cancer-specific survival did not differ significantly between the two treatments at any disease stage. Among the 576 patients with adenocarcinoma in the propensity-score-matched cohort, surgery was associated with significantly better overall survival in stages IB3 (HR 0.46, 95% CI 0.28–0.77) or IIA2 (HR 0.38, 95% CI 0.15–0.96) or IIB involving tumors < 4 cm (HR 0.36, 95% CI 0.16–0.80). It was also associated with significantly better cancer-specific survival in stages IB3 (HR 0.51, 95% CI 0.29–0.90), IIA2 (HR 0.22, 95% CI 0.07–0.76) or IIB involving tumors < 4 cm (HR 0.21, 95% CI 0.07–0.62). Conclusions: Surgery may be associated with better overall survival than radiotherapy in stage IB3 squamous cell carcinoma. In the case of adenocarcinoma, surgery may be associated with better overall and cancer-specific survival than radiotherapy in stage IB3 or IIA2 and in stage IIB involving tumors < 4 cm.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gynaecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China",
    "Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu Fan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Cheng-Wei Lian"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao-Yun Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin-Ke Li",
      "orcid": "0009-0008-6961-0495"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7jj391w88xnnm.bib",
  "cited_by": 0,
  "doi": "10.3390/cancers18203371",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702493/?tool=EBI",
  "id": "7jj391w88xnnm",
  "issns": [
    "2072-6694"
  ],
  "landing_url": "https://www.mdpi.com/2072-6694/18/20/3371",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|Endometrial and Cervical Cancer Treatments"
    ]
  ],
  "openalex": "W7222945656",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702493/pdf/?tool=EBI",
  "pmcid": "PMC13702493",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7jj391w88xnnm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:58Z",
      "native_id": "10.3390/cancers18203371",
      "source": "crossref",
      "url": "https://www.mdpi.com/2072-6694/18/20/3371"
    },
    {
      "first_seen": "2026-10-30T12:21:34Z",
      "native_id": "PMC:PMC13702493",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702493"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Endometrial and Cervical Cancer Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Comparison of Survival After Radical Hysterectomy or Radical Radiotherapy Among Patients with Different Histological Types of Locally Advanced Cervical Cancer: Analysis of SEER Data Using Propensity Score Matching",
  "title_text": "Comparison of Survival After Radical Hysterectomy or Radical Radiotherapy Among Patients with Different Histological Types of Locally Advanced Cervical Cancer: Analysis of SEER Data Using Propensity Score Matching",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:34Z",
  "url": "https://research.draconitic.com/paper/7jj391w88xnnm",
  "venue": "Cancers",
  "versions": []
}