{
  "abstract": "毒品成瘾以强迫性用药和戒断后的持续性渴求等为主要表现，长期毒品暴露还可能伴随奖赏、应激和执行控制等神经环路异常，以及骨密度降低、骨强度下降、骨转换紊乱、肌力减退及骨折风险升高等骨骼系统损害。毒品成瘾对神经系统和骨骼系统的损害可能并非相互独立，骨-脑轴通过神经、内分泌、免疫、代谢及骨源性因子等途径形成中枢神经系统和骨骼系统的双向调控，具体表现为长期毒品暴露通过交感神经系统、下丘脑-垂体-肾上腺轴及下丘脑-垂体-性腺轴影响骨重塑，并通过炎症免疫激活和氧化还原失衡同时扰乱脑和骨组织微环境；多巴胺、5-羟色胺和去甲肾上腺素等单胺类递质异常进一步连接成瘾相关神经行为改变和骨细胞功能失调；而骨钙素、硬化抑素、脂质运载蛋白2及骨源性细胞外囊泡等骨源性因子参与骨组织对脑功能的反馈调节。本文围绕毒品成瘾相关神经系统和骨骼系统共损害展开综述，分析骨-脑轴紊乱在两者关联中的潜在作用路径，以期为毒品成瘾躯体共病机制研究及综合干预策略构建提供参考。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "椅 杨",
      "orcid": "0000-0001-9370-4303"
    },
    {
      "name": "帅雄 廖"
    },
    {
      "name": "庭然 张"
    },
    {
      "name": "炯 罗",
      "orcid": "0009-0006-2158-5804"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7jma9jkqsj27e.bib",
  "cited_by": 0,
  "doi": "10.3724/zdxbyxb-2026-0001",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722849/",
  "id": "7jma9jkqsj27e",
  "issns": [
    "1008-9292"
  ],
  "landing_url": "https://doi.org/10.3724/zdxbyxb-2026-0001",
  "language": "zh",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Monographic Reports"
    ],
    [
      "heading",
      "R749.6"
    ],
    [
      "heading",
      "a"
    ],
    [
      "openalex",
      "1312|Bone Metabolism and Diseases"
    ]
  ],
  "openalex": "W7208769844",
  "pdf_url": null,
  "pmcid": "PMC13722849",
  "pmid": "42695208",
  "published": "2026-09-03",
  "publisher": "Zhejiang University Press",
  "ris": "https://research.draconitic.com/paper/7jma9jkqsj27e.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:36Z",
      "native_id": "PMC13722849",
      "source": "pmc",
      "url": "https://doi.org/10.3724/zdxbyxb-2026-0001"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bone Metabolism and Diseases",
      "subfield": "molecular-biology"
    }
  ],
  "title": "毒品成瘾相关神经系统和骨骼系统共损害骨-脑轴机制研究进展",
  "title_text": "毒品成瘾相关神经系统和骨骼系统共损害骨-脑轴机制研究进展",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:36Z",
  "url": "https://research.draconitic.com/paper/7jma9jkqsj27e",
  "venue": "Journal of Zhejiang University (Medical Sciences)",
  "versions": []
}