{
  "abstract": "The convergence of hypervirulence and multidrug resistance in K. pneumoniae poses a serious and emerging threat to global health. Here, we conducted genomic characterization of 40 dual carbapenemase-producing K. pneumoniae (DC-KP) isolates collected from a Chinese tertiary hospital. Whole-genome sequencing revealed that blaKPC-2/blaNDM-5 was the predominant carbapenemase combination, and most isolates belonged to the ST11 lineage. Low MICs of ATM + AVI and ATM + CZA were observed for 38 of the 40 DC-KP isolates, indicating substantial in vitro activity against most isolates in this cohort. Notably, we identified an ST23-KL1 K. pneumoniae isolate co-harboring blaKPC-2 and blaIMP-4 and carrying multiple hypervirulence-associated determinants. To our knowledge, this is the first report of an ST23-KL1 isolate with this combination of carbapenemase genes. RM/Anti-RM-associated gene counts differed among isolates with different carbapenemase profiles, warranting further investigation. These findings provide genomic insights into the coexistence of carbapenem resistance and hypervirulence-associated traits in K. pneumoniae.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Original Research",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Haijun Li"
    },
    {
      "name": "Saiqi Qi"
    },
    {
      "name": "Jilei Ma"
    },
    {
      "name": "Cailin Liu"
    },
    {
      "name": "Haiyang Meng"
    },
    {
      "name": "Fence Li"
    },
    {
      "name": "Xiaoxu Ma"
    },
    {
      "name": "Wanhai Wang"
    },
    {
      "name": "Shijun Sun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7jren8vtpap3y.bib",
  "cited_by": 0,
  "doi": "10.3389/fmicb.2026.1981105",
  "fulltext_url": null,
  "id": "7jren8vtpap3y",
  "issns": [
    "1664-302X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1981105",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "biology/microbiology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7jren8vtpap3y.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:20:43Z",
      "native_id": "10.3389/fmicb.2026.1981105",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1981105"
    },
    {
      "first_seen": "2026-11-02T12:23:22Z",
      "native_id": "10.3389/fmicb.2026.1981105",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fmicb.2026.1981105/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "feed-journal:biology/microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Genomic epidemiology of dual carbapenemase-producing Klebsiella pneumoniae and identification of an ST23-KL1 blaKPC-2/blaIMP-4 co-producing isolate in a Chinese tertiary hospital",
  "title_text": "Genomic epidemiology of dual carbapenemase-producing Klebsiella pneumoniae and identification of an ST23-KL1 blaKPC-2/blaIMP-4 co-producing isolate in a Chinese tertiary hospital",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T00:25:26Z",
  "url": "https://research.draconitic.com/paper/7jren8vtpap3y",
  "venue": "Frontiers in Microbiology",
  "versions": []
}