{
  "abstract": "Torreya grandis nuts are an important traditional Chinese medicine and a delicious food, and total flavonoids (TF) are its important bioactive ingredients. However, the arils are casually discarded during the processing of nuts. In order to explore the active ingredients and make full use of the arils, in this study, an eco-friendly and efficient method, ultrasonic assisted deep eutectic solvent (UAE-DES) extraction, was established to extract TF of the T. grandis arils (TGA). Under the RSM-ANN-GA optimization, the extraction method yielded 11.047 ± 1.921 mg/g of TF, which significantly surpassed that of traditional extractions. 28 flavonoids were identified from the TF via UPLC-Q-TOF/MS. Meanwhile, the obvious anti-inflammatory activities indicated that TF of TGA have an effective treatment on bronchitis by PI3K-AKT-MAPK pathway. Those findings demonstrate the high potential of UAE-DES extraction for the reuse and development of bioactive ingredients from the waste of traditional Chinese medicine and food.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China",
    "The First Clinical College, Guangdong Medical University, Zhanjiang 524023, Guangdong, China",
    "Chongqing Field Scientific Observation and Research Station for Authentic Traditional Chinese Medicine in the Three Gorges Reservoir Area, Chongqing University of Education, Chongqing 400067, China",
    "Zhejiang Key Laboratory of Chinese Medicine Modernization, Zhejiang Chinese Medical University, Hangzhou 311402, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gang Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Lizhu Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Bingxian Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingjin Bai"
    },
    {
      "affs": [
        0
      ],
      "name": "Jieqin Wei"
    },
    {
      "affs": [
        1
      ],
      "name": "Sihui Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Jie Lei"
    },
    {
      "affs": [
        0
      ],
      "name": "Qi Shi"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Luping Qin"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Huaqiang Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7jwybn5v6xraz.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ultsonch.2026.108134",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13734908/",
  "id": "7jwybn5v6xraz",
  "issns": [
    "1350-4177",
    "1873-2828"
  ],
  "landing_url": "https://doi.org/10.1016/j.ultsonch.2026.108134",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "openalex",
      "2704|Phytochemicals and Antioxidant Activities"
    ]
  ],
  "openalex": "W7223251202",
  "pdf_url": null,
  "pmcid": "PMC13734908",
  "pmid": "42945642",
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/7jwybn5v6xraz.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:42Z",
      "native_id": "PMC13734908",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ultsonch.2026.108134"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2704|Phytochemicals and Antioxidant Activities",
      "subfield": "general"
    }
  ],
  "title": "Ultrasonic assisted deep eutectic solvents extraction of flavonoids from arils of Torreya grandis: RSM-ANN-GA optimization, extraction mechanism and bioactivities",
  "title_text": "Ultrasonic assisted deep eutectic solvents extraction of flavonoids from arils of Torreya grandis: RSM-ANN-GA optimization, extraction mechanism and bioactivities",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:42Z",
  "url": "https://research.draconitic.com/paper/7jwybn5v6xraz",
  "venue": "Ultrasonics Sonochemistry",
  "versions": []
}