{
  "abstract": "Background: We examined whether contemporary serum trace-element categories were associated with reported first-degree family history of malignancy, rather than a relative’s historical exposure or the participant’s future cancer risk.\n\nMethods: This secondary exploratory cross-sectional analysis used archived data from 4,188 adults in SPES (Studio di Esposizione nella Popolazione Suscettibile), a population-based human-biomonitoring programme conducted in Campania, Italy, in 2016–2017. Relative-level reports were classified using documented rules and oncologist adjudication; a second registered physician independently reviewed a random 760-record subsample in a post hoc assessment during revision. Principal mixed-effects logistic models used observed median categories for 18 channels and quantified-versus-below-limit-of-quantification status for Be-9 and Pb-208, adjusting for age modelled with a restricted cubic spline, sex, participant smoking and SPES cluster. The 20 channels represented 19 elements. The original analysis inventory contained 258 hypothesis slots across nine separately corrected families; reviewer-requested sensitivities were reported separately.\n\nResults: Family history was positive in 1,040 of 4,185 classifiable participants (24.9%). Principal odds ratios ranged from 0.832 to 1.109 (minimum q = 0.730). Original upper-quartile and conditional malignancy-category findings did not survive their respective corrections. Category models compared a target malignancy with other malignancies among composite-positive histories, with incomplete site ascertainment. Additional stratum-adjusted, expanded-adjustment, quantified-range, broader-comparator and restrictive-definition principal/category families yielded no FDR-supported association. Cobalt met the within-set BH criterion only in a selected three-contrast expanded-Q4 sensitivity ( q = 0.019), not a panel-wide analysis. Independent binary agreement was 99.87% (757/758; κ = 0.9969); two indeterminate ratings were reported separately.\n\nConclusion: The tested serum categories did not identify a broad reported first-degree family-history signature. Nominal secondary patterns are hypotheses for independent replication, not validated exposure–cancer relationships. Classification reproducibility does not establish diagnostic accuracy or registry confirmation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Public Health, University of Naples Federico II",
    "Department of Health and Health Services, Regione Calabria",
    "Department of Human Sciences and Quality of Life Promotion, San Raffaele University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Carlo Buonerba"
    },
    {
      "affs": [
        0
      ],
      "name": "Paolo Montuori"
    },
    {
      "affs": [
        1
      ],
      "name": "Ernesto Esposito"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Maria Triassi"
    },
    {
      "affs": [
        0
      ],
      "name": "Pellegrino Cerino"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7jz83820k0y4b.bib",
  "cited_by": 1,
  "doi": "10.3389/fpubh.2026.1958224",
  "fulltext_url": null,
  "id": "7jz83820k0y4b",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1958224/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7jz83820k0y4b.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:43Z",
      "native_id": "10.3389/fpubh.2026.1958224",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1958224/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2296-2565",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Serum trace-element categories and reported first-degree family history of malignancy: an exploratory analysis of the SPES cohort",
  "title_text": "Serum trace-element categories and reported first-degree family history of malignancy: an exploratory analysis of the SPES cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:21:45Z",
  "url": "https://research.draconitic.com/paper/7jz83820k0y4b",
  "venue": "Frontiers in Public Health",
  "versions": []
}