{
  "abstract": "Intrathyroidal thymic carcinoma (ITTC) with neuroendocrine differentiation is rare, and evidence for definitive radiotherapy in nonsurgical patients remains limited. A 70-year-old woman with a 1-year history of a neck mass and hoarseness was diagnosed with ITTC with neuroendocrine differentiation based on histopathological, immunohistochemical, and imaging findings. After declining surgery and systemic chemotherapy, she received definitive radiotherapy: 60 Gy in 30 fractions to the planning target volume, followed by a sequential boost of 6 Gy in 3 fractions to the gross primary tumor and involved lymph nodes, for a cumulative dose of 66 Gy in 33 fractions. No grade ≥3 acute treatment-related toxicities occurred. At approximately 2 months after radiotherapy, the sum of target-lesion diameters decreased from 54 mm to 42 mm, a 22.2% reduction. With no new lesions or unequivocal progression of non-target disease, the overall response was classified as stable disease according to RECIST 1.1. This case documents early radiographic tumor reduction following definitive radiotherapy for ITTC, although longer follow-up is required to assess the durability of disease control and late toxicity.",
  "abstract_shown": true,
  "affiliations": [
    "The First Clinical Medicine College, Gansu University of Chinese Medicine , ,",
    "Department of Radiotherapy, Gansu Provincial Hospital , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jia Du"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiankai Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianbing Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Yunzhi Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaoyu Duan"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongyi Cai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7k4230dw78p4m.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1944330",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661400/?tool=EBI",
  "id": "7k4230dw78p4m",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13661400",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Myasthenia Gravis and Thymoma"
    ]
  ],
  "openalex": "W7214994417",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661400/pdf/?tool=EBI",
  "pmcid": "PMC13661400",
  "pmid": null,
  "published": "2026-09-30",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7k4230dw78p4m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:20Z",
      "native_id": "PMC:PMC13661400",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13661400"
    },
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1944330",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1944330/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Myasthenia Gravis and Thymoma",
      "subfield": "neurology"
    }
  ],
  "title": "Case Report: Definitive radiotherapy for intrathyroidal thymic carcinoma with neuroendocrine differentiation",
  "title_text": "Case Report: Definitive radiotherapy for intrathyroidal thymic carcinoma with neuroendocrine differentiation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:13Z",
  "url": "https://research.draconitic.com/paper/7k4230dw78p4m",
  "venue": "Frontiers in oncology",
  "versions": []
}