{
  "abstract": "Background: With the increasing burden of lean nonalcoholic fatty liver disease (NAFLD) and heart failure (HF), understanding the relationship between lean NAFLD and NT-proBNP in elderly patients becomes clinically important. This study aimed to identify the risk stratification value of combining NT-proBNP and lean NAFLD in elderly men with incident HF.\n\nMethods: The data from consecutive male patients aged 80 years or older, with incident HF of New York Heart Association class III/IV and a BMI less than 23 kg/m ² , who had available NT-proBNP measurements within 24 h of admission, were retrospectively analyzed. The clinical outcomes were 180-day all-cause and cardiovascular mortality.\n\nResults: A total of 3,627 patients were included. The levels of NT-proBNP were significantly higher in patients without lean NAFLD compared to those with lean NAFLD. After multivariate logistic regression, lean NAFLD remained independently associated with NT-proBNP category. Moreover, during the 180-day follow-up, Kaplan–Meier curves confirmed that patients with both lean NAFLD and NT-proBNP > 8330pg/mL had significantly higher all-cause and cardiovascular mortality compared to those with NT-proBNP alone.\n\nConclusion: NT-proBNP levels were higher in patients without lean NAFLD than in those with lean NAFLD. The coexistence of lean NAFLD and NT-proBNP > 8330 pg/mL was associated with increased all-cause and cardiovascular mortality in elderly normal-BMI men with incident HF.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Geriatric Cardiology, the Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinling Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinxin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuan Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoqian Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7k54vk70zz7ar.bib",
  "cited_by": 0,
  "doi": "10.3389/fcvm.2026.1846048",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710216/",
  "id": "7k54vk70zz7ar",
  "issns": [
    "2297-055X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1846048/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2705|Heart Failure Treatment and Management"
    ]
  ],
  "openalex": "W7221619831",
  "pdf_url": null,
  "pmcid": "PMC13710216",
  "pmid": "42947739",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/7k54vk70zz7ar.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "10.3389/fcvm.2026.1846048",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fcvm.2026.1846048/full"
    },
    {
      "first_seen": "2026-10-31T12:21:13Z",
      "native_id": "PMC13710216",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fcvm.2026.1846048"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Association of NT-proBNP with non-alcoholic fatty liver disease in elderly men with normal BMI and incident heart failure",
  "title_text": "Association of NT-proBNP with non-alcoholic fatty liver disease in elderly men with normal BMI and incident heart failure",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:13Z",
  "url": "https://research.draconitic.com/paper/7k54vk70zz7ar",
  "venue": "Frontiers in Cardiovascular Medicine",
  "versions": []
}