{
  "abstract": "Pediatric inflammatory bowel disease (IBD) patients are at increased risk for Clostridioides difficile infection. This review highlights bile acid dysmetabolism, driven by gut microbiota dysbiosis and reduced microbial production of secondary bile acids, as a key factor linking pediatric IBD to increased CDI susceptibility. We examine interactions among IBD, dysbiosis, bile acid metabolism, and C. difficile, and discuss emerging microbiome-based interventions aimed at restoring bile acid homeostasis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH USA.",
    "Comparative Hepatobiliary Intestinal Research Program (CHIRP), The Ohio State University, Columbus, OH USA."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "John C Rowe"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jenessa A Winston"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7k5n5mrqvwxvs.bib",
  "cited_by": 0,
  "doi": "10.1038/s44355-026-00084-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13739747",
  "id": "7k5n5mrqvwxvs",
  "issns": [
    "3004-9806"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996652",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7225347867",
  "pdf_url": "https://europepmc.org/articles/PMC13739747?pdf=render",
  "pmcid": "PMC13739747",
  "pmid": "42996652",
  "published": "2026-11-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7k5n5mrqvwxvs.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42996652",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996652"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Bile acid dysmetabolism and microbial dysbiosis coincide with Clostridioides difficile infection in pediatric inflammatory bowel disease.",
  "title_text": "Bile acid dysmetabolism and microbial dysbiosis coincide with Clostridioides difficile infection in pediatric inflammatory bowel disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/7k5n5mrqvwxvs",
  "venue": "Npj gut and liver",
  "versions": []
}