{
  "abstract": "Introduction\n\nClonal hematopoiesis (CH), defined as the expansion of a subset of hematopoietic stem or progenitor cells driven by acquired mutations, represents a novel cardiovascular risk factor. Its role in patients with high-grade carotid stenosis remains to be evaluated.Patients and methods\n\nNext-generation sequencing (NGS) involving 30 genes implicated in CH was used as diagnostic-grade assay (SOPHiA DDM Myeloid Solution) to screen for CH in 83 prospectively collected patients with symptomatic or asymptomatic high-grade carotid stenosis undergoing carotid endarterectomy (CEA).Results\n\nClonal markers were detected in 16 (19.7 %) of 83 patients (median age 71.2 years), with prevalence increasing at advanced age. At 5-year follow-up, CH carriers showed a higher cumulative incidence of major adverse cardiovascular events (MACE; P = 0.040) compared to patients without CH; all-cause mortality did not differ significantly between groups (P = 0.57). Cox regression revealed a significant association between CH and MACE in a univariable model (P = 0.047), which remained significant after multivariable adjustment for age and sex (P = 0.018). Exploratory analyses suggested that the association between CH and MACE may differ according to carotid stenosis severity, with an increased incidence of MACE observed in patients with <90 % stenosis and concomitant CH, an effect absent in patients with ≥90 % stenosis (P interaction = 0.03).Discussion and conclusions\n\nCH was associated with an adverse 5-year outcome in patients with carotid artery stenosis. These findings identify CH as a hematologic contributor to post-interventional cardiovascular risk and indicate that assessment of CH may offer additional prognostic information for residual risk stratification.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.",
    "Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.",
    "Division of Vascular Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria.",
    "Department of Pathology, Medical University of Vienna, Vienna, Austria.",
    "Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria.",
    "Core Facilities, Medical University of Vienna, Vienna, Austria.",
    "Department of Medicine IV, Clinic Hietzing, Vienna Healthcare Group, Vienna, Austria.",
    "Department of Laboratory Medicine, Clinic Hietzing, Vienna Healthcare Group, Vienna, Austria."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
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        0
      ],
      "name": "Olesya Harkot",
      "orcid": "0009-0004-6582-5393"
    },
    {
      "affs": [
        1
      ],
      "name": "Roland Jäger"
    },
    {
      "affs": [
        2
      ],
      "name": "Stephanie Kampf"
    },
    {
      "affs": [
        1
      ],
      "name": "Michael Gurbisz"
    },
    {
      "affs": [
        3
      ],
      "name": "Maja Carina Nackenhorst"
    },
    {
      "affs": [
        0,
        4,
        5
      ],
      "name": "Johann Wojta",
      "orcid": "0000-0002-1282-9276"
    },
    {
      "affs": [
        0
      ],
      "name": "Christian Hengstenberg"
    },
    {
      "affs": [
        6
      ],
      "name": "Bernhard Haring",
      "orcid": "0000-0001-6109-431X"
    },
    {
      "affs": [
        1
      ],
      "name": "Harald Esterbauer"
    },
    {
      "affs": [
        2
      ],
      "name": "Christoph Neumayer"
    },
    {
      "affs": [
        0
      ],
      "name": "Stefan Stojkovic"
    },
    {
      "affs": [
        1,
        7
      ],
      "name": "Svitlana Demyanets"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7k8ewtk0bfkr8.bib",
  "cited_by": 0,
  "doi": "10.1016/j.athplu.2026.100617",
  "fulltext_url": "https://europepmc.org/articles/PMC13677976",
  "id": "7k8ewtk0bfkr8",
  "issns": [
    "2667-0909",
    "2667-0895"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898635",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Cerebrovascular and Carotid Artery Diseases"
    ]
  ],
  "openalex": "W7215084469",
  "pdf_url": "https://europepmc.org/articles/PMC13677976?pdf=render",
  "pmcid": "PMC13677976",
  "pmid": "42898635",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7k8ewtk0bfkr8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898635",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898635"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Cerebrovascular and Carotid Artery Diseases",
      "subfield": "general"
    }
  ],
  "title": "Clonal hematopoiesis is associated with adverse events in patients with high-grade carotid artery stenosis.",
  "title_text": "Clonal hematopoiesis is associated with adverse events in patients with high-grade carotid artery stenosis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/7k8ewtk0bfkr8",
  "venue": "Atherosclerosis plus",
  "versions": []
}