{
  "abstract": "Fragile X messenger ribonucleoprotein (FMRP) is widely viewed as a translational repressor, yet its loss paradoxically compromises expression of exceptionally long, dosage-sensitive neurodevelopmental mRNAs. First shown in Drosophila oocytes, this selective loss extends to mouse cortex and hippocampus, but its mechanism remains unknown. Here, we uncover a protective function for FMRP: shielding long mRNAs from repression by Me31B/DDX6, a conserved RNA helicase that organizes repressive RNP complexes. In Drosophila oocytes, FMRP loss redirects target mRNAs into Me31B-marked P-bodies. Transcriptome-wide binding maps reveal extensive FMRP-Me31B co-occupancy, preferentially concentrated on long coding sequences whose translation depends on FMRP. Strikingly, disrupting Me31B-dependent repression preferentially enhances translation of FMRP targets in FMRP-deficient oocytes. We identify Rin/G3BP, Caprin, and Lig/UBAP2L as FMRP-associated cofactors supporting expression of distinct targets. Together, our findings challenge the prevailing view of FMRP as a translational repressor, revealing instead a mechanism that safeguards vulnerable neurodevelopmental mRNAs from inappropriate cytoplasmic silencing.",
  "abstract_shown": true,
  "affiliations": [
    "The University of British Columbia"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "K. Ma"
    },
    {
      "name": "A. R. Hossain"
    },
    {
      "name": "K. L. Judson"
    },
    {
      "name": "T. Q. Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "E. J. Greenblatt"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7kcec7mvcaqtb.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.07.23.739932",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.07.23.739932v2.full",
  "id": "7kcec7mvcaqtb",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.07.23.739932v2",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "molecular biology"
    ],
    [
      "openalex",
      "1311|Genetics and Neurodevelopmental Disorders"
    ]
  ],
  "openalex": "W7170801387",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.07.23.739932v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7kcec7mvcaqtb.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:39Z",
      "native_id": "10.64898/2026.07.23.739932",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.07.23.739932v2"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:molecular biology",
      "subfield": "molecular-biology"
    }
  ],
  "title": "FMRP safeguards long mRNA expression by opposing repressive RNP states",
  "title_text": "FMRP safeguards long mRNA expression by opposing repressive RNP states",
  "type": "preprint",
  "updated_at": "2026-11-09T00:20:52Z",
  "url": "https://research.draconitic.com/paper/7kcec7mvcaqtb",
  "venue": "bioRxiv",
  "versions": []
}