{
  "abstract": "Background: Yttrium oxide nanoparticles (Y2O3 NPs) are known as free radical absorbers. This study investigated the effects of Y2O3 NPs on antioxidant activities, liver enzymes, expression of alpha-smooth muscle actin (α-SMA) and transforming growth factor beta (TGF-β) genes, and histopathology in rat liver fibrosis.Methods: In this experimental study conducted in 2019 at Islamic Azad University, Qom, Iran, male Wistar rats (200–220 g) were assigned to seven groups (n=8): Control, Vehicle, carbon tetrachloride (CCl4), Y2O3 45 mg/Kg, Y2O3 60 mg/Kg, CCl4+Y2O3 45 mg/Kg, and CCl4+Y2O3 60 mg/Kg. Liver fibrosis was induced by CCl4. Y2O3 NPs were administered intraperitoneally for 4 weeks. Blood and liver samples were collected for analyses. Statistical analysis was performed using SPSS (version 21) by one-way ANOVA and Tukey post hoc test. P<0.05 was considered significant.Results: The findings indicated catalas (3.00±0.21 vs. 21.46±0.70, 8.96±20 U/min/mg, P<0.001), superoxide dismutase (3.13±0.21 vs. 44.36±1.99, 37.59±0.77 U/mg, P<0.001), glutathione peroxidase (135.25±4.02 vs. 492.00±27.87, 322.75±8.75, U/mg, P<0.001) activities increased, while malondialdehyde (1.29±0.86 vs. 0.32±0.03 , 0.49±0.06 nmol/mL, P<0.001), aspartate aminotransferase (286.33±2.89 vs. 154.66±9.00, 178.00±7.35 U/L, P<0.001), alkaline phosphatase (645.00±16.62 vs. 497.66±9.87, 321.75±20.03 U/L, P<0.001), gamma-glutamyl transferase (619.00±23.45 vs. 349.66±29.95, 299.25±2541 U/L, P<0.001) levels decreased. TGF-β and α-SMA expression decreased in terated groups (6.40±0.23 to 4.19±0.55, P=0.012, 2.70±0.46 P=0.009, 13.77 ±0.44 to 7.94±0.54 P=0.002, 4.87±0.35 P=0.033). Histology evaluatuons confirmed reduced inflammation, steatosis, and collagen deposition in Y2O3-treated fibrotic rats.Conclusion: Y2O3 NPs can alleviate liver fibrosis in experiment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran",
    "Department of Pathology, School of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fatemeh Danesh Pajooh"
    },
    {
      "affs": [
        0
      ],
      "name": "Shahrbanoo Oryan"
    },
    {
      "affs": [
        1
      ],
      "name": "Pejman Mortazavi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7kkbv95mq8k9q.bib",
  "cited_by": 0,
  "doi": "10.30476/ijms.2026.109288.4451",
  "fulltext_url": "https://europepmc.org/articles/PMC13743967",
  "id": "7kkbv95mq8k9q",
  "issns": [
    "0253-0716",
    "1735-3688"
  ],
  "landing_url": "https://doi.org/10.30476/ijms.2026.109288.4451",
  "language": "en",
  "licence": "CC-BY-ND",
  "licence_label": "CC BY-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "lcc",
      "R5-920"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://ijms.sums.ac.ir/article_52055_a0e2496a185e413acdf30c324deed165.pdf",
  "pmcid": "PMC13743967",
  "pmid": "42999531",
  "published": "2026-10-01",
  "publisher": "Shiraz University of Medical Sciences",
  "ris": "https://research.draconitic.com/paper/7kkbv95mq8k9q.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T14:21:11Z",
      "native_id": "064e21365c5543e99aa53f97b863e842",
      "source": "doaj",
      "url": "https://doi.org/10.30476/ijms.2026.109288.4451"
    },
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42999531",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999531"
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    {
      "first_seen": "2026-11-11T12:21:34Z",
      "native_id": "PMC13743967",
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      "url": "https://doi.org/10.30476/ijms.2026.109288.4451"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:R5-920",
      "subfield": "general"
    }
  ],
  "title": "Effect of Yttrium Oxide Nanoparticles on Liver Fibrosis Induced by Carbon Tetrachloride in Male Rats",
  "title_text": "Effect of Yttrium Oxide Nanoparticles on Liver Fibrosis Induced by Carbon Tetrachloride in Male Rats",
  "type": "peer-reviewed",
  "updated_at": "2026-11-11T12:21:34Z",
  "url": "https://research.draconitic.com/paper/7kkbv95mq8k9q",
  "venue": "Iranian Journal of Medical Sciences",
  "versions": []
}