{
  "abstract": "Type 2 diabetes (T2D) is a chronic metabolic disorder that significantly impacts skeletal health, including bones of the oral cavity, where alveolar bone is particularly susceptible due to its high remodeling rate and sensitivity to systemic metabolic changes. Using a mouse model of established T2D induced by high-fat diet and streptozotocin, we investigated the effects of the FDA-approved bone anabolic agents parathyroid hormone (PTH) and abaloparatide (ABL) on alveolar bone. In non-diabetic mice, PTH and ABL stimulated both bone formation and resorption, resulting in no net change in alveolar bone mass. In contrast, these agents selectively increased bone formation in T2D mice without further enhancing the already elevated resorption, leading to net alveolar bone gain. This anabolic effect involves suppression of sclerostin and Dickkopf-1 (Dkk-1) in osteocytes and activation of Wnt signaling in periodontal ligament cells. Studies using DMP1-Cre;PTH1Rfl/fl mice demonstrated that osteocytic PTH1R is essential for the anabolic effects but not for the bone resorption-promoting effects of PTH and ABL. These findings reveal a dual mechanism of PTH1R signaling in oral bone remodeling and suggest therapeutic strategies to restore alveolar bone and improve tooth retention and implant osseointegration in diabetic patients.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthodontics and Oral Facial Genetics, Indiana University School of Dentistry, Indianapolis, IN, USA.",
    "Department of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.",
    "Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.",
    "Indiana University School of Medicine, Indiana Center for Musculoskeletal Health, Indianapolis, IN, USA.",
    "Department of Biomedical Sciences and Comprehensive Care, Indiana University School of Dentistry, Indianapolis, IN, USA.",
    "University of Arkansas for Medical Sciences, Department of Physiology and Cell Biology, Little Rock, AR, USA.",
    "Department of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. yuanxue@iu.edu.",
    "Indiana University School of Medicine, Indiana Center for Musculoskeletal Health, Indianapolis, IN, USA. yuanxue@iu.edu.",
    "University of Arkansas for Medical Sciences, Department of Physiology and Cell Biology, Little Rock, AR, USA. TMBellido@uams.edu.",
    "Central Arkansas Veterans Healthcare System, John L. McClellan, Little Rock, AR, USA. TMBellido@uams.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hakan Turkkahraman"
    },
    {
      "affs": [
        1
      ],
      "name": "Carson Joseph Walton"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Yukiko Koizumi"
    },
    {
      "affs": [
        4
      ],
      "name": "Tianli Zhu"
    },
    {
      "affs": [
        5
      ],
      "name": "Nisreen Akel"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Xue Yuan",
      "orcid": "0000-0002-8063-9431"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Teresita M Bellido"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7kr9wvwmm7gbs.bib",
  "cited_by": 0,
  "doi": "10.1038/s41368-026-00470-3",
  "fulltext_url": "https://europepmc.org/articles/PMC13720201",
  "id": "7kr9wvwmm7gbs",
  "issns": [
    "1674-2818",
    "2049-3169"
  ],
  "landing_url": "https://europepmc.org/article/MED/42957662",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Bone Metabolism and Diseases"
    ]
  ],
  "openalex": "W7224263955",
  "pdf_url": "https://europepmc.org/articles/PMC13720201?pdf=render",
  "pmcid": "PMC13720201",
  "pmid": "42957662",
  "published": "2026-10-29",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/7kr9wvwmm7gbs.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:36Z",
      "native_id": "MED:42957662",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42957662"
    },
    {
      "first_seen": "2026-11-02T12:24:02Z",
      "native_id": "PMC13720201",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41368-026-00470-3"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bone Metabolism and Diseases",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Bone anabolic agents repair alveolar bone damaged by diabetes in mice.",
  "title_text": "Bone anabolic agents repair alveolar bone damaged by diabetes in mice.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:08Z",
  "url": "https://research.draconitic.com/paper/7kr9wvwmm7gbs",
  "venue": "International journal of oral science",
  "versions": []
}