{
  "abstract": "Post-stroke cognitive impairment (PSCI) is a common and debilitating neurological complication following cerebral ischemia-reperfusion injury (CIRI). The traditional neuron-centered view cannot fully explain its delayed onset, pathological heterogeneity, and functional plasticity. This review proposes a novel neuroecosystem framework based on the neurovascular-immune-glial (NIG) triad, including a systematic evaluation of the dynamic crosstalk among the neurovascular unit (NVU), neuronal networks, and glial-immune microenvironment. Pathological events, including ferroptosis, neuroinflammation, white matter damage, and gut-brain axis dysfunction, are reinterpreted as manifestations of neuroecosystem collapse, rather than isolated lesions. We further summarize cutting-edge tools, such as spatial omics and in vivo dynamic imaging for framework validation, and clarify how therapeutic strategies are shifting from single neuronal protection to overall ecosystem restoration. Finally, we discuss current limitations in knowledge and future research directions, aiming to provide new insights for mechanistic exploration and clinical intervention of PSCI.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Weifang Hospital of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, China.",
    "Department of Rehabilitation, Fujian Medical University, Fuzhou, China.",
    "Department of Rehabilitation, Weifang Hospital of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, China.",
    "Department of Endocrinology, Weifang Hospital of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, China.",
    "Clinical Integration of Traditional Chinese and Western Medicine, Shandong Second Medical University, Weifang, China.",
    "Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jiangbo Xie"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Tingting Zhang"
    },
    {
      "affs": [
        3
      ],
      "name": "Jinmei Zhang"
    },
    {
      "affs": [
        4
      ],
      "name": "Liping Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Tao Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenhua Bi"
    },
    {
      "affs": [
        0
      ],
      "name": "Manli Zhao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7mfvp1hyrfevn.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1912737",
  "fulltext_url": "https://europepmc.org/articles/PMC13639581",
  "id": "7mfvp1hyrfevn",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://europepmc.org/article/MED/42840724",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2808|Neurological Disease Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7213977342",
  "pdf_url": "https://europepmc.org/articles/PMC13639581?pdf=render",
  "pmcid": "PMC13639581",
  "pmid": "42840724",
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7mfvp1hyrfevn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42840724",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42840724"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Neurological Disease Mechanisms and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Cognitive impairment after cerebral ischemia-reperfusion injury: a neuroecosystem perspective.",
  "title_text": "Cognitive impairment after cerebral ischemia-reperfusion injury: a neuroecosystem perspective.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/7mfvp1hyrfevn",
  "venue": "Frontiers in neurology",
  "versions": []
}