{
  "abstract": "Bacterial infections compromise wound healing and represent a growing threat in the era of rising antibiotic resistance. Herein, we developed a multifunctional platform (CN@La@B) that combines bacterial capture, membrane sensitization, visible-light-triggered antibacterial activity, and anti-inflammatory effects. The CN@La@B was prepared by immobilizing dendritic mesoporous lanthanide hydroxide [La(OH)₃] nanoparticles (La NPs) onto graphite carbon nitride (g-C₃N₄) nanosheets to form a topologically structured La(OH)₃@g-C₃N₄ (CN@La) heterostructure, followed by loading of the anti-inflammatory agent berberine. The spiky topological La NPs attached to bacterial surfaces, thereby promoting phospholipid dephosphorylation and enhancing membrane permeability. Under visible-light irradiation, electrons from g-C₃N₄ nanosheets were photoexcited to the conduction band and subsequently transferred to La NPs, enabling electron-hole separation and reactive oxygen species generation to eradicate bacteria. Meanwhile, berberine loaded onto the CN@La@B platform helped regulate the wound immune microenvironment. Collectively, both in vitro and in vivo evaluations demonstrated that the CN@La@B killed bacteria and disrupted biofilms, while also modulating inflammation, speeding up wound closure, and supporting tissue regeneration. These findings suggest that CN@La@B is a promising multifunctional platform for infected wound treatment, based on a \"flypaper-mimicked\" antibacterial strategy that integrates bacterial capture, membrane sensitization, reactive oxygen species generation, and immunomodulation.",
  "abstract_shown": true,
  "affiliations": [
    "Shandong Provincial Hospital, School of Public Health, Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China.",
    "School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.",
    "State Key Laboratory of Animal Biotech Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.",
    "Shandong Medical and Pharmaceutical University, Yantai 264003, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ying Qu"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenyu Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Leilei Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyi Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Kejian Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhe Han"
    },
    {
      "affs": [
        2
      ],
      "name": "Shuai Gao"
    },
    {
      "affs": [
        3
      ],
      "name": "Huilin Zhao",
      "orcid": "0009-0006-4449-354X"
    },
    {
      "affs": [
        0
      ],
      "name": "Cong Song",
      "orcid": "0000-0002-1125-1089"
    },
    {
      "affs": [
        0
      ],
      "name": "Runxiao Zheng",
      "orcid": "0009-0006-3778-2415"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7mjgkb3xj4gjb.bib",
  "cited_by": 0,
  "doi": "10.34133/bmr.0436",
  "fulltext_url": "https://europepmc.org/articles/PMC13683949",
  "id": "7mjgkb3xj4gjb",
  "issns": [
    "1226-4601",
    "2055-7124"
  ],
  "landing_url": "https://europepmc.org/article/MED/42909224",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7221151635",
  "pdf_url": "https://europepmc.org/articles/PMC13683949?pdf=render",
  "pmcid": "PMC13683949",
  "pmid": "42909224",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7mjgkb3xj4gjb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909224",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909224"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Visible-Light-Enhanced Lanthanide Heterostructure with Synergistic Antibacterial and Anti-inflammatory Activity to Accelerate Wound Healing.",
  "title_text": "Visible-Light-Enhanced Lanthanide Heterostructure with Synergistic Antibacterial and Anti-inflammatory Activity to Accelerate Wound Healing.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/7mjgkb3xj4gjb",
  "venue": "Biomaterials research",
  "versions": []
}