{
  "abstract": "Précis:: Preoperative topical steroid use was associated with greater surgical success and thicker, less reflective bleb walls on anterior segment optical coherence tomography 1 year after trabeculectomy.\n\nPurpose:: To assess the associations of preoperative topical steroid administration with surgical outcomes and filtering bleb morphology 1 year after trabeculectomy.\n\nPatients and Methods:: This study included 304 eyes from 272 patients who underwent primary trabeculectomy with mitomycin C. Eyes were classified into steroid and nonsteroid groups based on preoperative topical steroid administration for 7 days. The primary outcome was surgical success at 1 year, defined by either criterion A [intraocular pressure (IOP) ≤15 mm Hg and a ≥20% reduction from preoperative IOP] or criterion B (IOP ≤12 mm Hg and a ≥30% reduction from preoperative IOP), achieved without glaucoma medication or additional glaucoma surgery. Bleb morphology was evaluated using anterior segment optical coherence tomography (AS-OCT). Multivariable Cox regression was used to adjust for potential confounders.\n\nResults:: At 1 year, surgical success rates were significantly higher in the steroid group than in the nonsteroid group for both criterion A (85.5% vs. 71.1%, P=0.005) and criterion B (76.4% vs. 65.4%, P=0.040). Preoperative steroid use was significantly associated with a lower hazard of surgical failure (criterion A: adjusted hazard ratio, 0.47; 95% CI: 0.27–0.82; P=0.008). Compared with the nonsteroid group, the steroid group exhibited greater bleb wall thickness (0.812 vs. 0.723 mm, P=0.038) and lower bleb wall reflectivity (130.3 vs. 141.9 arbitrary units, P=0.011).\n\nConclusions:: Preoperative administration of topical steroids, compared with no steroids, was associated with higher surgical success rates, thicker bleb walls, and lower bleb wall reflectivity on AS-OCT at 1 year.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ophthalmology, Okayama Saiseikai General Hospital, Okayama, Japan",
    "Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Tasuku Sunami",
      "orcid": "0009-0009-7762-3672"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Akiko Narita"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomoe Miyake"
    },
    {
      "affs": [
        0
      ],
      "name": "Momoka Miyake"
    },
    {
      "affs": [
        0
      ],
      "name": "Etsuko Akimoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Jiro Seguchi"
    },
    {
      "affs": [
        1
      ],
      "name": "Riku Akatsuka"
    },
    {
      "affs": [
        1
      ],
      "name": "Yuki Morizane"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7mmsd6mn2mejh.bib",
  "cited_by": 0,
  "doi": "10.1097/ijg.0000000000002775",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722419/",
  "id": "7mmsd6mn2mejh",
  "issns": [
    "1057-0829",
    "1536-481X"
  ],
  "landing_url": "https://doi.org/10.1097/ijg.0000000000002775",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Studies"
    ],
    [
      "openalex",
      "2731|Glaucoma and retinal disorders"
    ]
  ],
  "openalex": "W7222436086",
  "pdf_url": null,
  "pmcid": "PMC13722419",
  "pmid": "42886582",
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7mmsd6mn2mejh.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:22:55Z",
      "native_id": "PMC13722419",
      "source": "pmc",
      "url": "https://doi.org/10.1097/ijg.0000000000002775"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Glaucoma and retinal disorders",
      "subfield": "general"
    }
  ],
  "title": "Preoperative Topical Steroid Use and Trabeculectomy Outcomes",
  "title_text": "Preoperative Topical Steroid Use and Trabeculectomy Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:55Z",
  "url": "https://research.draconitic.com/paper/7mmsd6mn2mejh",
  "venue": "Journal of Glaucoma",
  "versions": []
}