{
  "abstract": "SUMMARY: B cell responses to cancer are critical to patient survival and response to therapy. Yet, the knowledge as to how B cells can elicit anti-tumor immunity remains incomplete. We identify that CD40 pathway activation in B cells in the presence of high tumor mutation burdens activates an anti-tumor B cell response. Significantly, our study shows that CD40-stimulated B cells drive tumor infiltration, organization, and activation of cytotoxic function in CD8+ T cells. These results provide key advances in the mechanistic regulation and function of B cell and CD8+ T cell responses to cancer.",
  "abstract_shown": true,
  "affiliations": [
    "Nomis Center for Immunobiology and Microbial Pathogenesis, Salk Cancer Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA",
    "University of California, San Diego, School of Biological Sciences, San Diego, CA 92093, USA",
    "These authors contributed equally",
    "Waitt Advanced Biophotonics Center Core Facility, Salk Institute for Biological Studies, La Jolla, CA 92037, USA",
    "University of California, San Diego, Department of Radiation Medicine & Applied Sciences, San Diego, CA 92093, USA",
    "Department of Systems Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA",
    "BC Cancer Deeley Research Centre, Victoria, BC V8R 6V5, Canada",
    "Senior author",
    "Lead contact"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Kendrick Nguyen"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Monika Quackenbush"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Basbous"
    },
    {
      "affs": [
        0
      ],
      "name": "Haley Rodriguez"
    },
    {
      "affs": [
        0
      ],
      "name": "Georgia Lattanzi"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Elsie Quansah"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Chynna Bowman"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Sammy Weiser Novak"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Daniela Boassa"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingting Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Taylor Ozbun"
    },
    {
      "affs": [
        4
      ],
      "name": "Asona Lui"
    },
    {
      "affs": [
        5
      ],
      "name": "Aatish Thennavan"
    },
    {
      "affs": [
        6
      ],
      "name": "Peter Watson"
    },
    {
      "affs": [
        0
      ],
      "name": "April Wehner"
    },
    {
      "affs": [
        0,
        1,
        4,
        7,
        8
      ],
      "name": "Daniel Hollern"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7msnk7ydaaa0t.bib",
  "cited_by": 0,
  "doi": "10.1016/j.celrep.2026.117957",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13716135/",
  "id": "7msnk7ydaaa0t",
  "issns": [
    "2211-1247"
  ],
  "landing_url": "https://doi.org/10.1016/j.celrep.2026.117957",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2403|Immunotherapy and Immune Responses"
    ]
  ],
  "openalex": "W7212172114",
  "pdf_url": null,
  "pmcid": "PMC13716135",
  "pmid": "42726639",
  "published": "2026-09-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7msnk7ydaaa0t.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:11Z",
      "native_id": "PMC13716135",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.celrep.2026.117957"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immunotherapy and Immune Responses",
      "subfield": "immunology"
    }
  ],
  "title": "B cell responses to CD40 stimulation ignite anti-tumor immunity by activating CD8+ T cell cytotoxicity",
  "title_text": "B cell responses to CD40 stimulation ignite anti-tumor immunity by activating CD8+ T cell cytotoxicity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:11Z",
  "url": "https://research.draconitic.com/paper/7msnk7ydaaa0t",
  "venue": "Cell reports",
  "versions": []
}