{
  "abstract": "Background/Objectives: Mixing implant components from different manufacturers in primary total hip arthroplasty (THA) remains controversial because of concerns regarding implant compatibility and revision risk. This systematic review and meta-analysis aimed to compare revision outcomes between brand-mixed and brand-unmixed primary THA. Methods: A PRISMA-compliant systematic review of PubMed/MEDLINE and Embase identified studies comparing brand-mixed and brand-unmixed primary THA. Reported time-to-event estimates were pooled as hazard ratios (HRs), and revision-event counts as odds ratios (ORs), using random-effects models. Results: Six retrospective observational studies comprising 1,185,948 primary THAs were included. The time-to-event analysis did not identify a statistically significant difference in all-cause revision between brand-mixed and brand-unmixed THA (HR 1.03; 95% CI 0.97–1.08; I2 = 0%). The complementary crude revision-event analysis likewise did not identify a statistically significant difference (OR 1.01; 95% CI 0.83–1.24), although substantial heterogeneity was present (I2 = 93%). A post hoc exploratory sensitivity analysis excluding metal-on-metal and ceramic-on-metal bearings and brand-mixed stem–head constructs was based on two studies and yielded an OR of 0.97 (95% CI 0.79–1.20; I2 = 95%). Certainty of evidence was low for the time-to-event analysis and very low for the event-based analyses. Conclusions: Available observational evidence did not identify a statistically significant association between brand mixing and all-cause revision following primary THA. However, these findings do not establish equivalence, universal component compatibility, or the safety of specific brand-mixed combinations and should be interpreted in light of the observational study designs, residual confounding, and heterogeneity in implant constructs.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Orthopedic and Trauma Surgery, Lucerne Cantonal Hospital, 6004 Lucerne, Switzerland",
    "Department of Health Science and Medicine, University of Lucerne, 6005 Lucerne, Switzerland"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Daniel Elias",
      "orcid": "0009-0008-5773-7018"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Bryan J. M. van de Wall",
      "orcid": "0000-0003-1882-8626"
    },
    {
      "affs": [
        0
      ],
      "name": "Jörg Bucher"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Björn-Christian Link",
      "orcid": "0000-0002-3289-6935"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pascal C. Haefeli"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7n4wd6h19kjhz.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15207904",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705420/?tool=EBI",
  "id": "7n4wd6h19kjhz",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/7904",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705420/pdf/?tool=EBI",
  "pmcid": "PMC13705420",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/7n4wd6h19kjhz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15207904",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/7904"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13705420",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705420"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Meta-Analysis of Brand-Mixed Versus Brand-Unmixed Primary Total Hip Arthroplasty",
  "title_text": "Meta-Analysis of Brand-Mixed Versus Brand-Unmixed Primary Total Hip Arthroplasty",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:40Z",
  "url": "https://research.draconitic.com/paper/7n4wd6h19kjhz",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}