{
  "abstract": "Background\n\nPhysical functioning has emerged as a potentially valuable prognostic indicator in patients with nonsmall cell lung cancer (NSCLC). This systematic review and meta-analysis aimed to evaluate the prognostic value of objectively measured components of physical functioning on survival outcomes across treatment modalities.Methods\n\nMedline, Web of Science and Scopus were searched up to May 2025. Eligible studies included adult patients with NSCLC and assessed at least one objectively measured physical functioning indicator in relation to survival outcomes. Indicators were categorised using the International Classification of Functioning, Disability and Health (ICF) framework into \"body functions and structures\", \"activities\" and \"participation\" and studies were stratified into \"surgery\" and \"nonsurgery\" groups. Meta-analyses were conducted when data permitted it.Results\n\n58 studies (19 436 patients) were included. Most assessments were performed before treatment. In the surgical group, only \"activities\"-based measures were evaluated. A meta-analysis restricted to this group showed that survivors had substantially higher (functional) exercise capacity, measured through cardiopulmonary exercise testing and field tests (standardised mean difference 0.79). In nonsurgical cohorts, prognostic value extended across all ICF domains, with low handgrip strength (hazard ratio (HR) 1.27), low (functional) exercise capacity (HR 2.11) and physical inactivity (HR 2.86) associated with significantly higher mortality. Notably, no studies in surgical cohorts evaluated \"body functions\" or \"participation\". Heterogeneity and varying thresholds were noted across studies.Conclusions\n\nObjectively measured physical functioning is a significant prognostic indicator of survival in NSCLC. Routine assessment could enhance risk stratification and guide personalised care. Future research should address longitudinal changes, standardisation of measures and targeted interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium.",
    "Shared first authors.",
    "REVAL-Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.",
    "BIOMED-Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.",
    "MOVANT Research Group, Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerp, Belgium.",
    "Department of Experimental-Health Psychology, Faculty of Health Psychology, Ghent University, Ghent, Belgium.",
    "Centre of Expertise in Care Innovation, Department of PXL - Healthcare, PXL University of Applied Sciences and Arts, Hasselt, Belgium.",
    "Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.",
    "Faculty of Medicine and Life Sciences, Hasselt University, Genk, Belgium.",
    "Department of Lung Diseases, Hospital Oost-Limburg, Genk, Belgium.",
    "Shared last authors.",
    "Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium heleen.demeyer@ugent.be."
  ],
  "article_type": "systematic review",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Eva Arents",
      "orcid": "0000-0001-8539-937X"
    },
    {
      "affs": [
        2,
        3,
        1
      ],
      "name": "Sarah Haesevoets",
      "orcid": "0000-0002-6841-9161"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Marthe Van Overbeke",
      "orcid": "0009-0008-5121-6537"
    },
    {
      "affs": [
        2,
        3,
        6
      ],
      "name": "Kirsten Quadflieg",
      "orcid": "0000-0002-3905-3180"
    },
    {
      "affs": [
        0
      ],
      "name": "Francesca Van Hulle",
      "orcid": "0009-0002-9491-7495"
    },
    {
      "affs": [
        7
      ],
      "name": "Bihiyga Salhi",
      "orcid": "0000-0003-1116-5401"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Maarten Criel",
      "orcid": "0000-0002-2591-6061"
    },
    {
      "affs": [
        7
      ],
      "name": "Dieter Stevens",
      "orcid": "0000-0002-2849-7042"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "David Ruttens"
    },
    {
      "affs": [
        7
      ],
      "name": "Veerle Surmont",
      "orcid": "0000-0003-0075-1114"
    },
    {
      "affs": [
        9
      ],
      "name": "Marc Daenen"
    },
    {
      "affs": [
        7
      ],
      "name": "Eric Derom",
      "orcid": "0000-0003-1110-4940"
    },
    {
      "affs": [
        2,
        3,
        10
      ],
      "name": "Chris Burtin",
      "orcid": "0000-0002-1342-8554"
    },
    {
      "affs": [
        11,
        10
      ],
      "name": "Heleen Demeyer",
      "orcid": "0000-0001-8925-0564"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7nfgwc0n1jemn.bib",
  "cited_by": 0,
  "doi": "10.1183/16000617.0230-2025",
  "fulltext_url": "https://europepmc.org/articles/PMC13684416",
  "id": "7nfgwc0n1jemn",
  "issns": [
    "0905-9180",
    "1600-0617"
  ],
  "landing_url": "https://europepmc.org/article/MED/42906942",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer survivorship and care"
    ]
  ],
  "openalex": "W7223147851",
  "pdf_url": "https://europepmc.org/articles/PMC13684416?pdf=render",
  "pmcid": "PMC13684416",
  "pmid": "42906942",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/7nfgwc0n1jemn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42906942",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42906942"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer survivorship and care",
      "subfield": "oncology"
    }
  ],
  "title": "The prognostic value of physical functioning on survival in patients with nonsmall cell lung cancer: a systematic review and meta-analysis.",
  "title_text": "The prognostic value of physical functioning on survival in patients with nonsmall cell lung cancer: a systematic review and meta-analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/7nfgwc0n1jemn",
  "venue": "European respiratory review : an official journal of the European Respiratory Society",
  "versions": []
}