{
  "abstract": "Background: Depressive symptoms are common among adults with hypertension and may interfere with the medication-taking and lifestyle behaviours required for long-term treatment. Evidence from Chinese primary care is limited, and most previous studies assessed medication-taking alone rather than overall treatment adherence.\n\nMethods: In this multicenter cross-sectional study conducted from January to December 2023, 2892 adults with physician-diagnosed hypertension were included from 12 primary health-care centres in Taizhou, Zhejiang Province, East China. Depressive symptoms were measured using the 9-item Patient Health Questionnaire (PHQ-9), and treatment adherence was measured using the Hypertension Treatment Adherence Scale (TASHP). Sequentially adjusted logistic regression was used to estimate associations, and restricted cubic splines described the dose-response relationship.\n\nResults: Of the 2892 participants (mean age 70.9 ± 10.4 years; 54.6% women), 1304 (45.1%) reported poor treatment adherence and 643 (22.2%) had PHQ-9 scores ≥5. In the fully adjusted model, a PHQ-9 score of ≥5 was associated with higher odds of poor adherence than a PHQ-9 score of 0–4 (adjusted odds ratio [aOR] 1.93, 95% confidence interval [CI] 1.59–2.33, P < 0.001). In a model with a linear term, each 1-point increase in PHQ-9 score was associated with a 12% increase in odds (aOR 1.12, 95% CI 1.09–1.16). Compared with scores of 0–4, the aOR was 1.89 (95% CI 1.56–2.30) for scores of 5–9 and 2.61 (95% CI 1.31–5.20) for scores of ≥10; the dose-response relationship was non-linear (P for non-linearity < 0.001).\n\nConclusion: Greater depressive symptom severity was associated with poorer self-reported treatment adherence among Chinese primary care patients. Prospective and interventional studies are warranted before depression screening or integrated care can be recommended to improve adherence.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pulmonary and Critical Care Medicine, Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, 310022, People’s Republic of China",
    "Geriatric Medicine Center, Department of Geriatric Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, People’s Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qingqing Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Li Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Dongsheng Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianhong Xie"
    },
    {
      "affs": [
        1
      ],
      "name": "Dibo Lao"
    },
    {
      "affs": [
        1
      ],
      "name": "Lin Wang",
      "orcid": "0000-0001-5994-4880"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/7nkp8sagqx2vj.bib",
  "cited_by": 0,
  "doi": "10.2147/ppa.s642856",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735419/",
  "id": "7nkp8sagqx2vj",
  "issns": [
    "1177-889X"
  ],
  "landing_url": "https://doi.org/10.2147/ppa.s642856",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2714|Medication Adherence and Compliance"
    ]
  ],
  "openalex": "W7224872715",
  "pdf_url": "https://www.dovepress.com/article/download/121641",
  "pmcid": "PMC13735419",
  "pmid": "42990829",
  "published": "2026-10-31",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/7nkp8sagqx2vj.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:06Z",
      "native_id": "PMC13735419",
      "source": "pmc",
      "url": "https://doi.org/10.2147/ppa.s642856"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2714|Medication Adherence and Compliance",
      "subfield": "general"
    }
  ],
  "title": "Association Between Depressive Symptom Severity and Treatment Adherence Among Primary Care Patients with Hypertension in Taizhou, East China: A Multicenter Cross-Sectional Study",
  "title_text": "Association Between Depressive Symptom Severity and Treatment Adherence Among Primary Care Patients with Hypertension in Taizhou, East China: A Multicenter Cross-Sectional Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:06Z",
  "url": "https://research.draconitic.com/paper/7nkp8sagqx2vj",
  "venue": "Patient preference and adherence",
  "versions": []
}